Risk factors analysis of obstructive sleep apnea in male patients with diabetes mellitus and coronary atherosclerotic heart disease
Tang Yadi
Zhou Yingsheng
Abstract：Objective To investigate the risk factors analysis of obstructive sleep apnea(OSA) in male patients with diabetes mellitus and coronary atherosclerotic heart disease.Methods From January 1st 2015 to June 30th,2018,211 male patients with diabetes mellitus and coronary atherosclerotic heart disease underwent sleep monitoring for breathing disorder in Beijing Anzhen Hospital,Capital Medical University,including 177 patients with OSA (OSA group) and 34 patients without OSA (control group).General information,laboratory results,coronary angiography findings and sleep monitoring parameters were retrospectively analyzed.Risk factors of OSA were screened by multivariate logistic regression.In OSA group there were 68 obese patients and 109 non-obese patients.OSA was graded as mild [sleep apnea hypopnea index (AHI) 5-＜ 15 events/h] and moderate-to-severe (AHI≥ 15 events/h).Results OSA group had higher body mass index,prevalence rate of hyperlipidemia,total eholesterol and high sensitive C-reactive protein levels than control group [(27.3 ± 2.7) kg/m2 vs (25.6 ± 2.2) kg/m2,20.9％ (37/177) vs 5.9％ (2/34),(4.1 ± 1.0) mmol/L vs (3.7 ± 0.9) mmol/L,3.1 (0.8,6.6) mg/L vs 1.3 (0.4,4.1) mg/L] (all P ＜ 0.05).Body mass index was an independent risk factor of OSA (odds ratio =1.243,95％ confidence interval:1.065-1.451,P =0.006).The optimal cut-off value of BMI in predicting OSA was 26.6 kg/m2 according to the receiver operator characteristic curve.Among non-obese patients there were higher levels of triglyceride,glycosylated hemoglobin,fasting blood sugar,high sensitive C-reactive protein and neutrophil percentage in patients with moderate-to-severe OSA as compared with patients with mild OSA(all P ＜0.05).Among obese patients there was higher incidence of coronary multivessel disease in patients with moderate-to-severe OSA as compared with patients with mild OSA (P ＜ 0.05).Conclusions Body mass index is an independent risk factor of OSA in male patients with diabetes mellitus and coronary atherosclerotic heart disease.Obese patients have higher incidence of coronary multivessel disease with more severe OSA.
Keywords：Diabetes mellitusCoronary atherosclerotic heart diseaseObstructive sleep apnea
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1661-1664 )