Predictive value of amplitude-integrated electroencephalogram for the severity and prognosis of hypoxic ischemic encephalopathy in full-term neonates with asphyxia
Li Hua
Qian Xiangming
Wei Hong
Abstract：Objective To investigate the value of amplitude-integrated electroencephalogram (aEEG) in predicting the severity and prognosis of hypoxic ischemic encephalopathy(HIE) in full-term neonates with asphyxia.Methods From January 2017 to January 2019,86 full-term neonates suffering from asphyxia who underwent aEEG monitoring in 6-12 h after birth in Maternal and Child Health and Family Planning Service Center of Mianyang,Sichuan Province were enrolled.They were divided into mild asphyxia group(49 cases) and severe asphyxia group (37 cases).Forty-five neonates developed HIE,including 13 cases of mild,23 cases of moderate and 9 cases of severe HIE.After comprehensive treatments,33 cases showed good response and 12 cases had poor prognosis.Early predictive value aEEG abnormality for the severity and prognosis of HIE was analyzed.Results Higher abnormal rates of aEEG background patterns and sleep-waking cycle(SWC) and higher incidence of eclampsia were observed with more severe asphyxia[severer asphyxia group vs mild asphyxia group:86.5％ (32/37) vs 14.3％ (7/49),64.9％(24/37) vs 24.5％ (12/49),48.6％ (18/37) vs 16.3％ (8/49)] and more severe HIE[severe HIE group vs mild and moderate groups:100.0％ (9/9) vs 46.5％ (6/13),91.3％ (21/23);100.0％ (9/9) vs 30.8％ (4/13),87.0％ (20/23);88.8％ (8/9) vs 0,69.6％ (16/23)] and poorer prognosis [poor prognosis group vs good prognosis group:100.0％ (12/12) vs 72.7％ (24/33),91.7％ (11/12) vs 66.7％ (22/33),83.3％ (10/12) vs 42.4％ (14/33)](all P ＜ 0.05).Spearman analysis showed that the severity and prognosis of HIE were correlated with aEEG abnormality (r =0.60,0.71;both P ＜ 0.05).Abnormal aEEG background patterns showed the highest sensitivity (84.4％),specificity (97.6％) and positive predictive value (95.0％) for HIE and the highest risk of poor prognosis(100.0％);the correct index was 0.82.Conclusion aEEG shows a good predictive value for HIE in full-term neonates with asphyxia.
Keywords：Neonatal asphyxiaHypoxic ischemic encephalopathyAmplitude-integrated electroencephalogramBrain injury
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1652-1655 )