Effect of continuous positive airway pressure ventilation combined with bovine alveolar surfactant on cerebral oxygen metabolism in neonates with respiratory distress syndrome
Wang Jierong
Li Huijuan
Huang Qian
Xiong Ying
Abstract：Objective To investigate the effect of continuous positive airway pressure(CPAP) ventilation combined with bovine alveolar surfactant on cerebral oxygen metabolism in infants with neonatal with respiratory distress syndrome(NRDS).Methods A total of 140 cases of NRDS admitted to Zhongnan Hospital of Wuhan University from January 2016 to December 2018 were randomly divided into control group and observation group,with 70 cases in each group.The control group was treated with CPAP ventilation on the basis of routine treatment.The observation group was treated with CPAP ventilation and bovine alveolar surfactant on the basis of routine treatment.Clinical efficacy,systemic oxygen metabolism indexes and cerebral oxygen saturation were analyzed.Results Total effective rate in observation group was significantly higher than that in control group[94.3％ (66/70) vs 82.9％ (58/70)] (x2 =2.547,P =0.012).CPAP ventilation time,oxygen uptaking time and hospitalization time in observation group were significantly shorter than those in control group(all P ＜ 0.05).After treatment,arterial partial pressure of oxygen and oxygenation index were improved in both groups,and the indexes in observation group was significantly higher than those in control group [(11.6 ± 2.1) kPa vs (10.3 ± 1.4) kPa,(23.6 ± 4.3) kPa vs (18.7 ± 3.2)kPa];arterial partial pressure of carbon dioxide and inhaled oxygen concentration reduced in both groups and they were lower in observation group than those in control group [(4.9 ± 1.1) kPa vs (5.5 ± 0.9) kPa,(32 ± 6) ％ vs (44 ± 5) ％] (all P ＜ 0.01).Cerebral oxygen saturation significantly rose during treatment in both groups (P ＜ 0.05),but gradually decreased at 10 and 30 min after treatment;no significant difference was noticed between groups (P ＞ 0.05).Conclusion CPAP ventilation combined with bovine alveolar surfactant treating NRDS can obviously improve cerebral oxygen metabolism.
Keywords：Neonatal respiratory distress syndromeContinuous positive airway pressure ventilationAlveolar surfactantCerebral oxygen metabolism
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1643-1646 )