Risk factors of aspirin resistance in patients with acute coronary syndrome
Zhao Honglei
Bai Tao
Xue Jinrong
Liu Yongmin
Sun Lizhong
Abstract：Objective To explore the risk factors of aspirin resistance (AR) in patients with acute coronary syndrome(ACS).Methods Totally 341 patients with ACS were enrolled in Beijing Anzhen Hospital,Capital Medical University from October 2015 to October 2018.According to platelet function testing results,the patients were divided into aspirin sensitive(AS) group(platelet aggregation rate≤20％,309 cases) and AR group (platelet aggregation rate ＞ 20％,32 cases).Basic information,drug use,laboratory indicators (creatinine clearance rate,serum uric acid,fasting blood glucose,triglyceride,total cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol and platelet count) were recorded to analyze the risk factors of AR.Results Incidence of AR was 9.4％ (32/341).In AR group there were more patients with type 2 diabetes history and smoking history and higher fasting blood glucose level as compared with AS group [62.5％ (20/32) vs 30.7％ (95/309),71.9％ (23/32) vs 53.4％ (165/309),6.3(5.2,10.0) mmol/L vs 5.6(5.0,6.8) mmol/L](all P ＜ 0.05).Multivariate logistic regression showed that type 2 diabetes history and smoking history were independent risk factors of AR(regression coefficient =1.422,0.956;odds ratio =4.417,2.602;95％ confidence interval:1.924-9.941,1.142-5.930;P＜0.001,P=0.023).Conclusion Type 2 diabetes history and smoking history are independent risk factors of AR in patients with ACS.
Keywords：Acute coronary syndromeAspirin resistanceRisk factor
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1614-1617 )