Relation of plasma homocysteine and high sensitive C-reactive protein with left ventricular hypertrophy in patients with H-type hypertension
Wang Hong
Kang Xiaoqin
Xie Wenbo
Fan Shiming
Chai Xiuying
Tian Huizhen
Abstract：Objective To explore the relation of plasma homocysteine (HCY) and high sensitive C-reactive protein(hs-CRP) levels with left ventricular hypertrophy in patients with H-type hypertension.Methods A total of 137 patients with essential hypertension and hyperhomocysteinemia were enrolled from January to December 2018 in Qinghai University Affiliated Hospital.Left ventricular mass index(LVMI) was measured by echocardiography.According to LVMI,the patients were divided into left ventricular hypertrophy group(78 cases) and normal group (59 cases).Systolic blood pressure(SBP),diastolic blood pressure(DBP),serum hs-CRP and Hcy levels were detected.Correlations between LVMI and above indicators were analyzed.Risk factors of left ventricular hypertrophy were analyzed by logistic regression.Results SBP,DBP,hs-CRP and Hcy in left ventricular hypertrophy group were significantly higher than those in normal group[(166 ± 13)mmHg vs (153 ± 10) mmHg,(96 ± 11)mmHg vs (87 ± 10) mmHg,(3.7 ± 1.9)g/L vs (2.6 ± 1.3)g/L,(16.1 ± 3.5)μmol/L vs (8.8 ± 1.6) μmol/L] (all P＜ 0.05).LVMI was positively correlated with SBP,DBP,hs-CRP and Hcy(r =0.451,P ＜ 0.001;r =0.493,P ＜ 0.001;r =0.327,P =0.002;r =0.272,P =0.009).Multivariate logistic regression showed that Hcy(odds ratio =1.208,95％ confidence interval:1.019-1.419,P =0.014) and hs-CRP(odds ratio =1.423,95％ confidence interval:1.152-1.705,P =0.021) were independent risk factors of left ventricular hypertrophy.Conclusions LVMI in patients with H-type hypertension is positively correlated with serum Hcy and hs-CRP levels.Hcy and hs-CRP are independent risk factors of left ventricular hypertrophy.
Keywords：HypertensionHomocysteineHigh sensitive C-reactive proteinLeft ventricular hypertrophyRisk factor
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1606-1609 )