Correlation among fasting blood glucose, metabolic syndrome and complex coronary artery disease in elective percutaneous coronary intervention patients with mildly elevated glycosylated hemoglobin
Yang Jie
Zhou Yujie
Zhao Ziwei
Zhang Tingyu
Cheng Zichao
Abstract：Objective To explore the correlation among fasting blood glucose(FBG),metabolic syndrome (MS) and complex coronary artery disease in patients with elevated glycosylated hemoglobin(HbA1 c) undergoing percutaneous coronary intervention (PCI).Methods Clinical data of 969 prediabetic patients (HbA1c 5.7％-6.4％)undergoing elective PCI from August to December 2017 in Beijing Anzhen Hospital,Capital Medical University were retrospectively analyzed.The patients were divided into impaired fasting glucose (IFG) group (6.1 mmol/L≤FBG ＜7.0 mmol/L,145 cases) and normal fasting glucose(NFG) group(FBG ＜ 6.1 mmol/L,824 cases).Prevalence and characteristics of MS and severity of coronary artery lesions were analyzed.Independent risk factors of MS were analyzed by logistic regression.Results IFG group had more overweight patients,more hyperglycemia and dyslipidemia(all P ＜ 0.05).Morbidity rate of MS in IFG group was significantly higher than that in NFG group [65.5％ (95/145) vs 20.4％ (168/824)] (P ＜ 0.001).Proportion of coronary three-vessel disease and Gensini score in IFG group were significantly higher than those in NFG group[33.8％ (49/145) vs 25.1％ (207/824),(39 ± 33) vs (31 ± 29)] (both P ＜ 0.05).Compared with non-MS patients,MS patients had higher proportion of three-vessel disease and higher Gensini score [37.3％ (98/263) vs 22.4％ (158/706),(43 ±28) vs (27 ± 26)] (both P ＜ 0.01).Logistic regression analysis showed that FBG and HbA1c were independently associated with MS(odds ratio =5.65,3.76;both P ＜0.001).Conclusions Prediabetic patients with elevated HbA1c and FBG have higher risk of MS and more complicated coronary lesions.HbA1c combined with FBG can evaluate the risk of MS and the severity of coronary artery disease in patients undergoing elective PCI.
Keywords：Percutaneous coronary interventionMetabolic syndromePrediabetesGlycosylated hemoglobinFasting blood glucose
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1601-1605 )