Risk factors of portal venous thrombosis in cirrhosis patients with ascites infection and the predictive value of evaluation model
Hu Liping
Xiong Jingping
Nulibiya Abudukeyoumu
Zhang Yuexin
Abstract：Objective To investigate the risk factors of portal venous thrombosis ( PVT ) in cirrhosis patients with ascites infection and the predictive value of evaluation model. Methods Totally 388 cases of cirrhosis with ascites infection were enrolled from March 2015 to March 2018 in the First Affiliated Hospital of Xinjiang Medical University;38 patients with PVT were observation group and 350 patients without PVT were control group. Laboratory indicators, imaging findings and complications were recorded to analyze the influence factors of PVT and to obtain a Logit equation;the predictive value of Logit model was evaluated. Results White blood cell count in observation group was significantly higher and platelet distribution width( PDW) , hemoglobin,γ-glutamyl transferase (γ-GT) and albumin levels were significantly lower than those in control group(all P<0. 05). Internal diameter of main portal vein, internal diameter of splenic vein and volume of peritoneal effusion in observation group were significantly greater than those in control group[(12 ± 5)mm vs (11 ± 5)mm, (9. 7 ± 2. 6)mm vs (8. 0 ± 2. 3)mm, (4. 1 ± 2. 2)ml vs (2. 4 ± 1. 3)ml](all P<0. 05). Incidences of spontaneous peritonitis, portal hypertensive gastropathy (PHG), esophageal and gastric varices, upper gastrointestinal bleeding(UGIB) in observation group were significantly higher than those in control group(all P<0. 05). Logistic regression showed that PHG, UGIB,γ-GT and PDW were risk factors of PVT. Logit P=2. 031-0. 025 ×γ-GT(U/L) +0. 35 × PDW(mm) +1. 912 × PHG(yes=1, no=0) +1. 713 × UGIB(yes=1, no=0); the accuracy of equation was 82. 372％. Conclusions Reduction of γ-GT can reduce the incidence of PVT in cirrhosis patients with ascites infection. PHG and UGIB may increase the risk of cirrhotic ascites infection with PVT. Logit model shows a good predictive value for PVT.
Keywords：Cirrhosis ascites infectionPortal vein thrombosisRisk factorsEvaluation model
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1524-1527 )