Clinical effectiveness and hemorheological changes by using Sanqi Tongshu capsule combined with acupuncture and moxibustion treating hemiplegia due to cerebral infarction

Li Jing; Zhang Lingzhi; Zeng Zhechun

doi:10.3760/j.issn.1673-4777.2019.10.015

Abstract：Objective To observe the clinical effectiveness and hemorheological changes in patients with hemiplegia due to cerebral infarction treated by Sanqi Tongshu capsule combined with acupuncture and moxibustion. Methods Eighty patients with hemiplegia caused by cerebral infarction were enrolled from September 2015 to June 2016 in Beijing Anzhen Hospital, Capital Medical University. They were randomly divided into observation group and control group, with 40 cases in each group. Four cases in control group and 2 cases in observation group dropped out during the trial. The observation group took routine antihypertensive drug, lipid-lowering drugs and Sanqi Tongshu capsule(0. 2 g/capsule, 1 capsule/time, 3 times/d) for 6 months. The control group only took routine antihypertensive and lipid-lowering drugs. Both groups had acupuncture and moxibustion therapy for 10 days as a course of treatment, intermittent for 2 days, and they were treated 10 courses in total. Whole blood viscosity and hematocrit were detected before and after treatment. Clinical therapeutic effect and the influence factors were analyzed. Results Therapeutic effect in observation group was significantly better than that in control group(Z= -2. 886,P=0. 004). After treatment, whole blood viscosity and hematocrit were improved compared with those before treatment in both groups, and the levels in observation group were obviously lower than those in controlgroup[(5.64±0.30)mPa·svs(7.13±0.28)mPa·s,(38.9±2.5)％ vs(45.6±3.0)％](both P<0. 05). Multivariate logistic regression analysis showed that simple drug therapy and smoking were independent risk factors of the therapeutic effect(odds ratio=0. 040, 0. 003;95％ confidence interval:0. 003-0. 549, 0. 000-0. 156; P = 0. 016, 0. 004 ); self-health management behavior was an independent protective factor of the therapeutic effect(odds ratio=18. 432, 95％ confidence interval:1. 635-207. 792, P=0. 018) (all P<0. 05). Conclusions Sanqi Tongshu capsule combined with acupuncture and moxibustion treating hemiplegia caused by cerebral infarction is effective in improving the cure rate and hemorheological indicators with no significant adverse reaction. With adjustment of confounding factors, Sanqi Tongshu capsule combined with acupuncture and moxibustion shows a better curative effect than acupuncture and moxibustion therapy.