Clinical effect of atorvastatin combined with enalapril maleate folic acid tablets on cognitive impairment following acute cerebral infarction in elderly patients with H-type hypertension and the influence on stress response proteins, neuron specific enolase and S100 β levels
Liu Bingjian
Zhao Liling
Abstract：Objective To observe the clinical effect of atorvastatin combined with enalapril maleate folic acid tablets on cognitive impairment following acute cerebral infarction in elderly patients with H-type hypertension and the influence on stress response protein, neuron specific enolase( NSE) and S100β levels. Methods From September 2017 to February 2019, 100 elderly patients with H-type hypertension, acute cerebral infarction and cognitive impairment admitted to Wuhan No. 1 Hospital were randomly divided into control group and observation group, with 50 cases in each group. The control group took enalapril maleate folic acid tablets. The observation group took atorvastatin and enalapril maleate folic acid tablets. Blood pressure, homocysteine, cognitive function, cortisol, adrenaline, NSE and S100β levels were analyzed. Results After treatment, systolic blood pressure and homocysteine level significantly decreased in both groups;the levels in observation group were lower than those in control group [ ( 130 ± 10 ) mmHg vs ( 137 ± 12 ) mmHg, ( 8. 8 ± 1. 5 )μmol/L vs ( 10. 7 ± 2. 2)μmol/L](all P<0. 05). Scores of memory, attention and calculation, recall, orientation and language significantly increased after treatment and the scores in observation group were higher than those in control group (all P<0. 05). Levels of cortisol, adrenaline, NSE and S100β significantly decreased after treatment and the levels in observation group were lower than those in control group[(199 ± 10)μg/L vs (212 ± 9)μg/L, (91 ±9)ng/L vs (101 ± 10)ng/L, (2. 3 ± 0. 5)μg/L vs (3. 6 ± 0. 5)μg/L, (2. 0 ± 0. 5)μg/L vs (2. 8 ± 0. 5)μg/L] (all P<0. 05). Conclusion Atorvastatin combined with enalapril maleate folic acid tablets can effectively reduce blood pressure in elderly patients with H-type hypertension and actue cerebral infarction, improve the cognitive ability and the recovery of abnormal stress response proteins, NSE and S100β levels.
Keywords：Acute cerebral infarctionH-type hypertensionCognitive dysfunctionAtorvastatinEnalapril folate maleate tabletsStress response
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1474-1478 )