Correlation between tissue factor and blood lipid in patients with coronary atherosclerotic heart disease
Wang Mei
Li Yanfang
Guo Yanqing
Chen Mengmeng
Jiang Zhili
Song Junying
Abstract：Objective To explore the relationship between tissue factor ( TF ) and blood lipid levels in patients with coronary atherosclerotic heart disease( CHD) . Methods A total of 210 patients who visited Beijing Anzhen Hospital, Capital Medical University because of chest pain were enrolled from July 2013 to March 2014. According to coronary angiographic findings after admission, the patients were divided into CHD group(120 cases) and control group(90 case). The CHD group was divided into acute coronary syndrome(ACS) group(31 cases) and stable CHD(SCHD) group(89 cases). Clinical data including fasting blood routine and biochemical tests were collected. Results Serum TF level was positively correlated with neutrophil count and high sensitivity C-reactive protein(hs-CRP) level in CHD patients(r =0. 232, P =0. 011; r =0. 571, P =0. 012). Multivariate logistic regression showed that diabetes, low density lipoprotein cholesterol(LDL-C) and hs-CRP were independent risk factors of CHD(all P<0. 05). TF level in ACS group was significantly higher than that in SCHD group and control group[(129 ± 23)ng/L vs (116 ± 20),(114 ± 36)ng/L](P<0. 05). In ACS group, LDL-C level was positively correlated with TF level(r=0. 609, P=0. 001). Conclusion Serum LDL-C level is positively correlated with TF level in ACS patients, suggesting that LDL-C and TF may be involved in atherosclerotic plaque rupture.
Keywords：Coronary atherosclerotic heart diseaseLow density lipoprotein cholesterolTissue factor
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1467-1469 )