Therapeutic effect of recombinant human growth hormone on severe burn patients

Liang Min; Ji Peng

doi:10.3760/j.issn.1673-4777.2019.09.021

Abstract：Objective To explore the effect of recombinant human growth hormone (rhGH) on severe burn patients.Methods Totally 102 cases of severe burn patients undergoing selective surgery were enrolled at the First Affiliated Hospital of Air Force Medical University from February 2014 to April 2016.The patients were randomly divided into observation group and control group,with 51 cases in each group.On the basis of routine medication and nursing after surgery,the control group was given 2 ml 0.9％ sodium chloride injection as placebo and the observation group was given subcutaneous injection of rhGH before bedtime for 10 days.Levels of growth hormone,cortisol,blood sugar,insulin,glucagon,prealbumin and total protein,subeschar healing time of donor site,skin graft and deep second-degree burn area,and length of hospital stay were analyzed.Results Growth hormone level significantly increased in the observation group since 3 days after surgery compared to that in the control group (P ＜ 0.05).Levels of blood sugar and insulin in the observation group were significantly higher compared to those in the control group since 3 days and 7 days after surgery(all P ＜ 0.05).At 7,10,15 days after surgery,levels of plasma prealbumin and total protein in the observation group were significantly higher than those in the control group (all P ＜ 0.05).Healing time of donor site,skin graft and deep second-degree burn and hospitalization time in the observation group were signifcantly shorter than those in the control group[(8.8 ± 2.5)d vs (13.4 ±2.7)d,(25 ±6)d vs (37 ±9)d,(21 ±3)d vs (29 ±4)d,(51 ±6)d vs (69 ±9)d] (all P＜0.05).Conclusion RhGH treating severe burn can improve body metabolism,promote protein synthesis,accelerate wound healing and shorten the cure time.