Relation between fasting blood glucose and osteocalcin in healthy young men with normal glucose tolerance

Fan Dongmei; Wu Guangfei; Liu Junru; Wang Xing; Liu Bowei; Yin Fuzai

doi:10.3760/j.issn.1673-4777.2019.09.017

Abstract：Objective To investigate the relation between fasting blood glucose and osteocalcin in healthy young men with normal glucose tolerance.Methods Totally 138 healthy young men with normal glucose tolerance were enrolled in First Hospital of Qinhuangdao from January to December 2015.Body mass index,fasting blood glucose (FBG),fasting insulin,homeostasis model assessment insulin resistance index(HOMA-IR) and serum bone metabolism indexes [osteocalcin (OC),procollagen type Ⅰ N-terminal propeptide (PINP),procollagen type Ⅰ C-terminal peptide(CTX)] were tested.Bone mineral densities of lumbar vertebra 1-4,femoral neck and whole body were detected by dual energy X-ray absorptiometry.According to the quartiles of FBG,the patients were divided into 4 groups:group A (31 cases,FBG ＜ 5.1 mmol/L),group B (29 cases,5.1 mmol/l ≤ FBG ＜5.3 mmol/L),group C(39 cases,5.3 mmol/L≤FBG ＜5.6 mmol/L),group D(39 cases,FBG≥5.6 mmol/L).Relation between FBG and the other indicators was analyzed.Results There were significant differences of body mass index,HOMA-IR,OC and CTX among the 4 groups (P ＜ 0.05);OC in group D was significantly lower than that in group C [(35 ± 4) μg/L vs (37 ± 3) μg/L,P =0.004];CTX in group D was significantly higher than that in group C[(1.4 ±0.7) μg/L vs (1.1 ±0.4) μg/L,P =0.042].With adjustments of age and body mass index,FBG was negatively correlated with OC(r'=-0.202,P =0.018).Logistic regression showed that men with FBG ≥5.6 mmol/L had a significant higher risk of OC reduction than men with FBG ＜ 5.6 mmol/L (odds ratio =10.117,95％ confidence interval:2.300-44.503,P=0.002).Conclusion In healthy young men with normal glucose tolerance,OC decreased and CTX rose with the increase of FBG within normal range,suggesting that FBG may be an early indicator of bone metabolism.