Therapeutic effect of piracetam combined with levetiracetam on epilepsy in children and the effect on cognitive function

Zhou Tian; Pu Lihua; Zhu Xieying

doi:10.3760/j.issn.1673-4777.2019.09.015

Abstract：Objective To explore the therapeutic effect of piracetam combined with levetiracetam on children with epilepsy and the effect on cognitive function.Methods Totally 100 children with epilepsy admitted to Xi'an Children's Hospital from January 2015 to June 2018 were randomly divided into observation group and control group,with 50 cases in each group.The control group was treated with levetiracetam and the observation group was treated with levetiracetam plus piracetam.Serum levels of high mobility group protein 1 (HMGB1),insulin-like growth factor-1 (IGF-1),interleukin-6 (IL-6),immunoglobulin (Ig) A and IgG were detected.Cognitive function was assessed by Wechsler Intelligence Scale for Children-Chinese Revision(WISC-CR).Therapeutic effect and complications during treatment were observed.Results After treatment,levels of serum HMGB1,IGF-1,IL-6,IgA and IgG significantly decreased and the levels in observation group were significantly lower than those in control group [(4.2 ± 0.6)μg/L vs (5.1 ± 0.7) μg/L,(66 ± 8) μg/L vs (74 ± 9) μg/L,(6.6 ± 0.6)ng/L vs (7.1 ±0.7)ng/L,(0.52±0.11)g/L vs (1.23 ±0.23)g/L,(6.1 ±0.4)g/L vs (6.6 ±0.6)g/L](all P ＜ 0.05).WISC-CR score significantly increased after treatment and the score in observation group was significantly higher than that in control group [(87 ± 10) vs (80 ± 10)] (P ＜ 0.05).Total effective rate in observation group was significantly higher than that in control group [96.0％ (48/50) vs 82.0％ (41/50)] (P =0.03).Incidence of complications in observation group was significantly lower than that in control group [6.0％ (3/50) vs 20.0％ (10/50)] (P =0.04).Conclusion Piracetam combined with levetiracetam treating epilepsy in children can effectively regulate the expression of inflammatory factors,improve cognitive function and reduce complications.