Effect of moxifloxacin combined with drug infusion by fiberbronchoscope on immune function and inflammatory factors in patients with multi-drug resistant pulmonary tuberculosis
Yang Huiwei
Li Donglei
Li Runpu
Lin Zhenhuai
Lao Jingdong
Wang Xiaojie
Abstract：Objective To observe the clinical efficacy of moxifloxacin combined with drug infusion by fiberbronchoscope in treatment of multi-drug resistant pulmonary tuberculosis and its influence on immune function and inflammatory factors.Methods A total of 100 patients with multi-drug resistant pulmonary tuberculosis admitted to the Second Central Hospital of Baoding City,Hebei Province from January 2013 to January 2016 were randomly divided into control group and observation group,with 50 cases in each group.On the basis of routine drug treatment,the control group was given levofloxacin orally,while the observation group was given moxifloxacin orally combined with drug infusion by fiberbronchoscope.Clearance rate of bacteria in sputum was tested 3,6,9 months after treatment;absorption rate of lung foci in X-ray was observed 9 months after treatment.Serum contents of T cell subsets CD3+,CD4+,CD8+,CD4+/CD8+,interleukin(IL)-2,IL-6 and C-reactive protein(CRP)were analyzed before and after treatment.Results The 3-,6-and 9-month clearance rates of bacteria in sputum and the 9-month absorption rate of lung foci in X-ray in observation group were significantly higher than those in control group[50.0％ (25/50) vs 42.0％ (21/50),72.0％ (36/50) vs 52.0％ (26/50),86.0％ (43/50) vs 62.0％ (31/50),90.0％ (45/50) vs 60.0％ (30/50)] (all P ＜0.05).After treatment,serum levels of CD3+,CD4+ and CD4+/CD8+ increased in both groups;the levels in observation group were significantly higher than those in control group;serum levels of CD8+,IL-2,IL-6 and CRP decreased and the levels in observation group were significantly lower than those in control group (all P ＜ 0.05).Conclusion Moxifloxacin combined with drug infusion by fiberbronchoscope shows better clinical effect than levofloxacin on sputum bacterial clearance and lung lesion recovery in treating multi-drug resistant pulmonary tuberculosis;it can also effectively regulate serum T cell subsets,IL-2,IL-6 and CRP levels.
Keywords：Multi-drug resistant pulmonary tuberculosisMoxifloxacinFiberoptic bronchoscopyDrug infusionT cell subsets
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1336-1339 )