Effect of bisoprolol on myocardial function and vascular endothelial function in hypertensive patients with angina pectoris
Wang Lin
Xu Shaoxin
Liu Zhihong
Abstract：Objective To investigate the effect of bisoprolol on myocardial function and vascular endothelial function in hypertensive patients with angina pectoris.Methods A total of 108 hypertensive patients with angina pectoris admitted to Traditional Chinese Hospital of LuAn,Anhui Province from March 2017 to March 2018 were treated with bisoprolol for 4 weeks.Clinical efficacy was observed.Heart rate,blood pressure,left ventricular ejection fraction,cardiac output,cardiac index,left ventricular end-systolic diameter,left ventricular end-diastolic diameter,endothelin-1,nitric oxide and angiotensin Ⅱ levels were measured before and after treatment.Results After treatment,65 cases were markedly effective,30 cases were effective and 13 cases were ineffective;the total effective rate was 88.0％ (95/108).There were no significant changes of heart rate,left ventricular ejection fraction and cardiac index (all P ＞ 0.05).Systolic and diastolic blood pressures after treatment were significantly lower than those before treatment [(119 ± 18) mmHg vs (156 ± 20) mmHg,(74 ± 10) mmHg vs (96 ± 16)mmHg] (both P ＜0.01).Cardiac output after treatment was significantly higher while left ventricular end-systolic and end-diastolic diameters were significantly lower than those before treatment[(5.0 ± 0.6)L/min vs (4.7 ± 0.8) L/min,(47 ±± 5) mm vs (53 ± 5) mm,(50 ± 5)mm vs (57±4)mm] (all P ＜ 0.01).Plasma levels of endothelin-1 and angiotensin Ⅱ after treatment were significantly lower and nitric oxide level was significantly higher than those before treatment[(58 ±6)ng/L vs (66 ± 10) ng/L,(49 ± 16)ng/L vs (65 ± 18)ng/L,(47 ± 7)μmol/L vs (42 ±7) μ mol/L] (all P ＜0.01).Conclusion Bisoprolol treating hypertensive patients with angina pectoris can effectively suppress blood pressure,relieve angina symptoms,improve myocardial function and vascular endothelial function.
Keywords：HypertensionAnginaBisoprololVascular endothelial functionMyocardial function
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1314-1316 )