Risk factors of long-term prognosis in elderly patients with advanced gastric cancer after chemotherapy

Ye Zhenjun; Deng Minghui

doi:10.3760/j.issn.1673-4777.2019.08.020

Abstract：Objective To investigate the risk factors of long-term prognosis in elderly patients with advanced gastric cancer after chemotherapy.Methods Two hundreds elderly patients with advanced gastric cancer admitted to the Sixth People's Hospital of Huizhou,Guangdong Province from January 2013 to October 2015 were recruited.According to patients' condition and tumor characteristics,different regimens were applied for neoadjuvant chemotherapy,with an average of 4 cycles.All patients were followed up for 3 years;related factors of the 3-year survival rate of elderly patients with advanced gastric cancer were analyzed;risk factors of the 3-year survival rate were analyzed by logistic regression.Results Follow-up for 3-year;121 patients survived and 79 patients died;the 3-year survival rate was 60.5％ (121/200).There were no significant differences of the 3-year survival rate among patients with different gender,clinical stage,tumor location,lymph node dissection area,hypertension and distant metastasis (all P ＞ 0.05).Lower 3-year survival rates were observed in patients with tumor diameter ＞ 7 cm,poor differentiated tumor,diabetes mellitus and lymph node metastasis [53.4％ (63/118) vs 70.7％ (58/82),48.8％ (59/121) vs 78.5％ (62/79),45.6％ (26/57) vs 66.4％ (95/143),49.6％ (67/135) vs 83.1％ (54/65)],the differences were statistically significant (all P ＜ 0.05).Multivariate logistic regression showed that tumor diameter ＞ 7 cm,poor differentiation and lymph node metastasis were risk factors of the 3-year survival in elderly patients with advanced gastric cancer (all P ＜ 0.05).Conclusion There are many factors influencing the long-term prognosis in elderly patients with advanced gastric cancer after neoadjuvant chemotherapy;tumor diameter,differentiation and lymph node metastasis are the risk factors.