Effect of rabeprazole on peptic ulcer and relevant organism indexes
Zhang Xu
Abstract：Objective To explore the therapeutic efficacy of rabeprazole in treatment of peptic ulcer and its effect on serum procollagen type Ⅰ N-terminal propeptide(PINP),collagen type I C-terminal peptide β-specific sequence (β-CTX) and transforming growth factor-β1 (TGF-β1).Methods Totally 113 patients with peptic ulcer patients admitted to Zhejiang Hospital from August 2014 to September 2016 were divided into control group(55 cases)and observation group(58 cases) according to random number table method.The control group was treated with omeprazole,amoxicillin and clindamycin;the observation group was treated with rabeprazole,amoxicillin and clindamycin.Eradication rate of Helicobacter pylori (Hp),symptom score,levels of gastrin,motilin,hemorheological indexes,PINP,β-CTX and TGF-β1 were analyzed.Results Eradication rate of Hp in observation group was significantly higher than that in control group[91.4％ (53/58) vs 72.7％ (40/55)] (P ＜0.05).After treatment,symptom score significantly decreased and there was no significant difference between groups [(6.8 ± 1.2) vs (7.0 ± 1.0)] (P ＞ 0.05).Levels of gastrin and motilin significantly decreased after treatment in both groups;the levels in observation group were lower than those in control group [(82 ± 12)ng/L vs (102 ± 14)ng/L,(359 ± 13) ng/L vs (390 ± 16) ng/L] (all P ＜ 0.05).Plasma viscosity,erythrocyte sedimentation rate and erythrocrit significantly decreased after treatment;the indexes in observation group were lower than those in control group [(1.13 ±0.11)mPa · s vs (1.56 ±0.13)mPa · s,(7.2± 1.2)mm/1 h vs (12.4 ± 1.2)mm/1 h,(31 ±4)％ vs (37 ± 5)％] (all P ＜ 0.05).Serum level of PINP significantly increased and TGF-β1 level decreased after treatment;PINP level in observation group was higher and TGF-β1 level was lower than those in control group [(31.2 ±1.3)μg/Lvs (27.5 ±1.2)μg/L,(812 ±80)ng/Lvs (1 025 ±102)ng/L](all P＜0.05).There was no significant difference of serum β-CTX level between groups before and after treatment (all P ＞ 0.05).Conclusion Rabeprazole treating peptic ulcer can effectively relieve clinical symptoms,improve hemorheological indexes,regulate serum PINP and TGF-β1 levels.
Keywords：Peptic ulcerRabeprazoleOmeprazoleGastrinHemorheology
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1196-1199 )