Clinical efficacy and neurological effect of minimally invasive puncture and drainage combined with edaravone on hypertensive intracerebral hemorrhage

Sun Wei; Chen Zhenying; Yang Xiaoli

doi:10.3760/j.issn.1673-4777.2019.08.014

Abstract：Objective To explore the therapeutic effect of minimally invasive puncture and drainage combined with edaravone on hypertensive intracerebral hemorrhage (HICH) and its influence on neurological function.Methods Totally 100 patients with HICH admitted to Qinghai Provincial People's Hospital from January 2015 to December 2017 were randomly divided into control group and observation group,with 50 cases in each group.The control group was treated with minimally invasive puncture and drainage.The observation group was treated with minimally invasive puncture and drainage combined with edaravone.Clinical efficacy,cerebral hematoma and edema volume before and 14 d after treatment,scores of National Institutes of Health Stroke Scale (NIHSS),Glasgow Coma Scale(GCS),Chinese Stroke Scale(CSS) and Activity of Daily Living(ADL),levels of serum interleukin-6 (IL-6),tumor necrosis factorα (TNF-α) and C-reactive protein (CRP) were analyzed.Results The total effective rate in observation group was significantly higher than that in control group [86.0％ (43/50) vs 60.0％ (30/50)] (P =0.015).After treatment,cerebral hematoma and edema significantly reduced in both groups;the volumes in observation group were significantly lower than those in control group [(10.4±1.4)mlvs (16.2±1.6)ml,(1.2±0.5)ml vs (2.1 ±0.7)ml](P＜0.05).After treatment,NIHSS score and CSS score in both groups were significantly lower than those before treatment;NIHSS score and CSS score in observation group were significantly lower than those in control group[(20.1 ± 1.7) vs (23.5 ± 1.5),(9.1 ± 1.1) vs (12.2 ± 1.0)];GCS score and ADL score were significantly higher than those before treatment;GCS score and ADL in observation group were significantly higher than those in control group [(4.9 ± 0.5) vs (4.0 ± 0.4),(66 ± 6) vs (44 ± 5)] (P ＜ 0.05).After treatment,serum levels of IL-6,TNF-α and CRP in both groups were significantly lower than those before treatment;the levels in observation group were significantly lower than those in control group[(43 ± 6)ng/L vs (75 ± 7)ng/L,(38 ± 5)ng/L vs (54 ± 6)ng/L,(10.2 ± 1.4)mg/L vs (19.5 ± 1.3) rng/L] (all P ＜ 0.05).Conclusion Minimally invasive puncture and drainage combined with edaravone treating HICH can effectively promote the recovery of neurological function and improve the quality of life.