Effect of ulinastatin combined with thymosin on respiratory function and inflammatory stress response in patients with severe pneumonia

Fu Yu; Wu Shaomin; Zeng Zhaofan

doi:10.3760/j.issn.1673-4777.2019.08.010

Abstract：Objective To explore the effect of ulinastatin combined with thymosin on respiratory function,inflammatory and stress response in patients with severe pneumonia.Methods Sixty-three patients with severe pneumonia admitted to Hainan General Hospital from September 2015 to April 2017 were randomly divided into control group (31 cases) and observation group (32 cases).The control group was treated with routine therapy;the observation group was treated with ulinastatin and thymosin on the basis of routine therapy.Blood gas indexes,inflammatory markers,inflammatory cytokines,stress response indexes and score of Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) were analyzed.Results After treatment,arterial partial pressure of carbon dioxide,levels of procalcitonin,C-reactive protein,D-dimer,tumor necrosis factor-a,interleukin-6,malondialdehyde and APACHE Ⅱ score were significantly lower in the observation group than those in the control group [(60 ±7) mmHg vs (66 ±7)mmHg,(5.5 ±2.1)μg/L vs (7.4 ±2.7) μg/L,(5.3 ±2.0) mg/L vs (7.6 ±2.5) mg/L,(2.7±1.2)mg/L vs (4.9 ±1.7)mg/L,(34±10)ng/L vs (43 ±11)ng/L,(25 ±9)ng/L vs (38 ±10)ng/L,(6.4 ± 1.2) μmol/L vs (7.5 ± 1.4) μmol/L,(14 ± 4) vs (17 ± 6)];arterial partial pressure of oxygen,arterial oxygen saturation,interleukin-10 and superoxide dismutase levels in the observation group were significantly higher than those in the control group[(92 ± 12) mmHg vs (83 ± 11) mmHg,(96 ± 11)％ vs (89 ± 10)％,(26 ±5)ng/L vs (18 ±4)rig/L,(88 ± 18)U/L vs (71 ± 17)U/L] (all P ＜0.05).Conclusion Ulinastatin combined with thymosin can obviously improve respiratory function and blood gas,reduce inflammation and stress response in patients with severe pneumonia.