Effect of dizocine combined with ketamine on painless gastroscopy in the elderly

Zhang Saihua; Xiao Qun; Wang Yaping

doi:10.3760/j.issn.1673-4777.2019.07.020

Abstract：Objective To observe the clinical effect of dezocine combined with ketamine on painless gastroscopy in elderly patients.Methods A total of 120 patients undergoing painless gastroscopy in the Second Xiangya Hospital of Central South University from October 2016 to October 2017 were randomly divided into 3 groups,with 40 cases in each group.The group A had anesthesia with dezocine 0.05 mg/kg + ketamine 0.05 mg/kg + propofol 1.5-2.5 mg/kg;the group B had dezocine 0.05 mg/kg + propofol 1.5-2.5 mg/kg;the group C had propofol 1.5-2.5 mg/kg alone.Mean arterial pressure(MAP),heart rate(HR) and pulse oxygen saturation (SpO2) were recorded before operation,after eyelash reflex disappeared,during operation and after operation.Propofol consumption,operating time,awakening time,scores of Visual Analogue Scale (VAS) at 2,4,8,12,24,48 h after operation and the incidence of side effects were analyzed.Results MAP,HR and SpO2 in group A and B were significantly higher than those in group C after eyelash reflex disappeared and during operation(all P ＜0.05).Intraoperative propofol dosage in group A was significantly less than that in group B and C[(106 ± 19) mg vs (137 ± 19),(182 ± 27) mg];awakening time in group A and B was significantly shorter than that in groupC[(5.1 ±1.7),(5.4±1.4)min vs (7.2±2.1)min](allP＜0.05).At 4,8,12 h after operation,VAS scores in group A and B were significantly lower than those in group C[(2.9 ±0.6),(2.8 ±0.7) vs (3.2±0.6);(2.4±0.5),(2.4±0.6) vs (2.9±0.6);(2.0±0.4),(2.0±0.6) vs (2.5±0.6)](allP＜ 0.05).Incidences of intraoperative motion,cough,dizziness and headache,nausea and vomiting showed significant differences among the 3 groups;the incidences of intraoperative motion,nausea and vomiting in group A were significantly lower than those in group B [0 vs 12.5％ (5/40),0 vs 10.0％ (4/40)] (both P ＜ 0.05).Conclusion Dezocine combined with ketamine shows a good anesthesia effect and few side effects on elderly patients undergoing painless gastroscopy.