Effect of tacrolimus combined with Bailing capsules on fasting blood glucose and renal function in patients after liver transplantation

Xie Fang; Wang Lu; Chen Dexi; Zhang Jing; Lin Minghua; Cai Ze; Ding Yuechao; Shi Ying; Pang Lijun; Lin Dongdong

doi:10.3760/j.issn.1673-4777.2019.07.019

Abstract：Objective To evaluate the effect of tacrolimus combined with Bailing capsules on fasting blood glucose and renal function in patients after liver transplantation.Methods Clinical data of 73 patients who had liver transplantation from January 2007 to December 2011 in Beijing YouAn Hospital,Capital Medical University were analyzed.All patients were treated with tacrolimus and hormones in the first 3 months after surgery.Three months later,they were divided into control group(13 cases) treated with tacrolimus and observation group (60 cases) treated with tacrolimus plus Bailing capsules.Blood glucose,liver and kidney function indexes were analyzed 1,2,3 years after surgery.Results Levels of fasting blood glucose,urea nitrogen and creatinine in observation group were significantly lower than those in control group at 2 and 3 years after surgery(all P ＜ 0.05).In observation group,there was no significant changes of fasting blood glucose,blood urea nitrogen and creatinine levels in 1,2,3 years after surgery(all P ＞ 0.05);blood uric acid level at 3 years was significantly higher than that at 1 year after surgery [(389 ± 120) μmol/L vs (316 ± 118) μmol/L] (P ＜ 0.01).The total incidence of hyperuricemia and the incidence of hyperuricemia in males at 2,3 years were significantly higher than those at 1 year after surgery in observation group(all P ＜ 0.05).Conclusions Tacrolimus combined with Bailing capsules treating patients after liver transplantation can effectively increase blood urea nitrogen and creatinine levels,delay the progression of chronic renal failure,but it shows no significant effect on blood glucose and uric acid.The combined medication shows no obvious adverse reaction.