Efficacy of Chinese medicine combined with chemotherapy in treatment of advanced breast cancer: a meta-analysis of randomized controlled trials
Wu Xiaoqing
Li Juan
Lu Wenping
Abstract：Objective To systematically evaluate the efficacy and safety of traditional Chinese medicine (TCM) combined with chemotherapy in the treatment of advanced breast cancer.Methods Clinical randomized controlled trials(RCTs) of TCM combined with chemotherapy treating grade Ⅲ-Ⅳ breast cancer published before December 2018 were searched in CNKI,Wanfang,VIP,Chinese BioMedical Literature Database,PubMed and Cochrane Library;the control group was treated with same chemotherapy scheme alone.Valid data were extracted and quality of literatures was evaluated.Stata 12.0 software was used for meta-analysis.Main endpoint was overall response rate;secondary outcomes were TCM syndrome score and digestive adverse reaction.Results A total of 25 RCTs involving 1 553 patients were included.Meta-analysis showed that compared to chemotherapy-alone,TCM combined with chemotherapy significantly increased the overall response rate,the relative risk =1.27 (95％ confidence interval:1.16-1.39);TCM syndrome score was significantly improved,the relative risk =1.40 (95 ％ confidence interval:1.20-1.62);TCM therapy according to syndrome differentiation combined with chemotherapy could reduce digestive adverse reactions,the relative risk =0.67 (95％ confidence interval:0.55-0.82)(all P ＜ 0.01).Conclusion TCM combined with chemotherapy treating advanced breast cancer can improve the overall response rate,relieve syndromes and reduce digestive adverse reactions.
Keywords：Advanced breast cancerTraditional Chinese medicineChemotherapyMeta-analysis
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：6( 1023-1028 )