Clinical effect of liraglutide on patients with type 2 diabetes mellitus and obesity
Ye Xiayun
Zhao Jinying
Han Fengxia
Abstract：Objective To observe the therapeutic effect of liraglutide on patients with type 2 diabetes mellitus and obesity.Methods From January 2016 to January 2018,46 obese patientswith type 2 diabetes with poor response to metformin were enrolled in the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army.The patients were randomly divided into observation group (24 cases) and control group (22 cases).The control group was treated with metformin plus insulin glargine injection.The observation group was treated with metformin plus liraglutide.Fasting plasm glucose (FBG),2 h postprandial blood glucose (2 h PG),glycosylated hemoglobin (HbA1c) and body mass index (BMI) were analyzed before and 24 weeks after treatment.Results There was no significant difference of FBG,2 h PG,HbA1c and BMI between groups before treatment(all P ＞0.05).Levels of FBG,2 h PG and HbAlc decreased significantly after 24 weeks of treatment in both groups (all P ＜0.05).After treatment,levels of 2 h PG and HbA1c in observation group were significantly lower and FBG was significantly higher than those in control group [(7.6 ± 1.5) mmol/L vs (8.6 ± 1.9) mmol/L,(6.3 ±1.2)％ vs (7.1±1.4)％,(7.2±2.0)mmol/Lvs (6.0±2.0)mmol/L](t=2.053,2.086,2.033;P =0.046,0.043,0.048).BMI showed no significant changes in control group(P ＞0.05).BMI in observation group after treatment was significantly lower than that before treatment and that in control group [(25 ± 5)kg/m2 vs (29 ± 4)kg/m2] (both P ＜ 0.01).Conclusion Liraglutide can effectively control blood glucose and reduce body weight in patients with type 2 diabetes and obesity.
Keywords：Type 2 diabetes mellitusLiraglutideObesity
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1004-1006 )