Hemostatic effect of new hemostatic material combined with arterial compression device on patients with transradial coronary intervention

Suo Min; Nie Shaoping; Ai Hui; Que Bin; Wang Chunmei; Zhen Lei

doi:10.3760/j.issn.1673-4777.2019.07.005

Abstract：Objective To investigate the hemostatic effect of chitosan,a new hemostatic material,combined with radial artery compression,on patients with coronary interventional therapy via transradial approach.Methods A total of 130 patients undergoing coronary angiography with right radial artery access in Beijing Anzhen Hospital,Capital Medical University from February to July 2017 were randomly divided into experimental group(60 cases,using chitosan and arterial compression device) and control group (70 cases,using arterial compression device).Clinical data and operation records were analyzed.Hemostatic effect was evaluated by the duration of compression,right palm swelling and patient satisfaction.Results Baseline data and main laboratory indices showed no significant difference between groups (P ＞ 0.05).Intraoperative heparin dosage,postoperative activated coagulation time and rate of stent implantation showed no significant difference between groups (P ＞0.05).Duration of compression in experimental group was significantly shorter than that in control group [(250 ± 32) min vs (379 ± 39) min] (P ＜ 0.001).Postoperative right plam swelling and compression successful release rate showed no significant difference between groups(P =0.359,0.133).Patient satisfaction of hemostatic effect in experimental group was significantly higher than that in control group [58.3 ％ (35/60) vs 40.0％ (28/70)](P =0.037).Conclusions Chitosan combined with arterial compression shows a good hemostatic effect on patients with transradial coronary intervention.It can shorten compression time,improve patient satisfaction and provide a preferable hemostasis method for transradial procedure.