Epidemiological and laboratory characteristics of children with positive results of mycoplasma pneumoniae RNA by simultaneous amplification and testing
Qu Teng
Tian Wenjun
Wang Minghui
Liu Yiqing
Liu Chunmei
Qiu Yang
Zhang Qing
Cui Chaojie
Abstract：Objective To investigate the prevalence and epidemiological characteristics of mycoplasma pneumoniae(MP) infection in children in Shandong Province;to analyze the characteristics of laboratory tests in MP RNA-positive children detected by simultaneous amplification and testing(SAT) and provide references for clinical diagnosis and prevention.Methods A total of 604 children with acute respiratory infection admitted to Shandong Provincial Hospital Affiliated to Shandong University from January to December 2017 were enrolled.MP RNA was tested by SAT.Epidemiological and laboratory characteristics were analyzed.Results There were 109 MP RNA-positive children and the positive rate was 18.0％.MP RNA-positive rate was 22.0％ (40/182) in female and 16.4％ (69/422) in male(P ＞0.05).There was a significant difference of MP RNA-positive rate among children aged 0-3 years[10.6％ (46/436)],4-7 years [41.2％ (49/119)] and 8-14 years [28.6％ (14/49)] (P ＜ 0.05).MP RNA-positive rates in spring,summer,autumn and winter were 9.0％ (13/144),17.1％ (19/111),29.6％ (60/203) and 11.6％ (17/146),respectively;there was a significant difference among seasons (P ＜ 0.05).Among the 109 patients with positive results of MP RNA,C-reactive protein increased in 44 cases(40.4％) and it was normal in 65 cases(59.6％);white blood cell count increased in 53 cases(48.6％);red blood cell count decreased in 30 cases(27.5％);hemoglobin decreased in 47 cases(43.1％);platelet count increased in 59 cases (54.1％);7 children showed normal results of blood routine test.Seventeen of 36 children had normal cellular immune function;C16+CD56+ increased in 3 cases and dropped in 7 cases;CD19+ increased in 15 cases and dropped in 1 case;CD3+ dropped in 5 cases;CD3+ CD4+ dropped in 11 cases;CD3+ CDs+ increased in 2 cases.Conclusions MP infection is associated with age and season but not with gender.Effective preventive measures should be made for the prevention and treatment of MP infection based on significant characteristics of the disease in different region.MP RNA testing is helpful for the accurate assessment of MP infection;laboratory assistant examination can provide necessary references for the diagnosis.
Keywords：Mycoplasma pneumoniaeSimultaneous amplification and testing
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 874-878 )