The value of 64-slice CT low-dose dual-phase scanning lung density in the evaluation of lung function in patients with chronic obstructive pulmonary disease
Feng Guang
Yang Lingzhi
Ji Junyu
Wang Xinju
Zheng Hao
Bai Hongzhong
Abstract：Objective To investigate the value of 64-slice CT low-dose dual-phase scanning lung density in the evaluation of pulmonary function in patients with chronic obstructive pulmonary disease (COPD).Methods From January 2017 to February 2018,67 patients with COPD (COPD group) and 50 healthy people (control group) were recruited in Hebei Chest Hospital.All subjects had 64-slice CT low-dose dual-phase scanning;lung density and lung function indexes were analyzed.Results Deep end-inspiratory density (Din),deep end-expiratory density (Dex),density difference (Dex-Din) and density change percentage [(Din-Dex)/Din]in COPD group were significantly lower and Dex/Din was significantly higher than those in control group [(-860 ±60)Hu vs (-830 ±54)Hu,(-801 ±80)Hu vs (-701 ±76)Hu,(59±23)Hu vs (125 ±41)Hu,(0.07 ± 0.01) vs (0.17 ± 0.16),(0.97 ± 0.26) vs (0.85 ± 0.21)] (all P ＜ 0.05).Forced expiratory volume in the first second as a percentage of the predicted value(FEV1 ％) and the ratio of forced expiratory volume in the first second to forced vital capacity(FEV1/FVC％) in COPD group were significantly lower than those in control group[(55 ±12)％ vs (89±11)％,(57 ±13)％ vs (83 ±12)％](all P＜0.05).FEV1％ was positively correlated with Dex,Dex-Din and (Din-Dex)/Din (r =0.487,0.511,0.522;all P ＜ 0.05) and negatively correlated with Dex/Din (r =-0.477;P ＜ 0.05);FEV1/FVC％ was positively correlated with Din,Dex,Dex-Din and (Din-Dex)/Din (r =0.422,0.563,0.521,0.517;all P ＜ 0.05) and negatively correlated with Dex/Din(r =-0.500;P ＜ 0.05).Conclusion 64-slice CT low-dose dual-phase scanning lung density can be used to evaluate the lung function of COPD patients.
Keywords：Chronic obstructive pulmonary diseasePulmonary functionMulti-slice CTLow-dose dual-phase scanningLung density
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 862-865 )