Effect of dexmedetomidine on renal function in patients undergoing coronary artery bypass grafting with extracorporeal circulation

Jia Zhaojin; Li Xiuhua

doi:10.3760/j.issn.1673-4777.2019.06.012

Abstract：Objective To investigate the effect of dexmedetomidine on renal function in patients undergoing coronary artery bypass grafting with extracorporeal circulation.Methods Eighty patients undergoing coronary artery bypass grafting with extracorporeal circulation in Tangshan Gongren Hospital Affiliated to North China University of Science and Technology from June 2014 to June 2016 were randomly divided into observation group and control group,with 40 cases in each group.The observation group was administered dexmedetomidine 4 mg/L,1 μg/(kg · h) and the control group was administered same volume of 0.9％ sodium chloride solution 1 μg/(kg· h) from before anesthesia induction to the end of operation.Blood urea nitrogen(BUN),serum creatinine(Scr) and cystatin C(Cys C) were tested before operation,at the end of operation,24 h and 48 h after operation.Urine volume was recorded during operation and within 24 h after operation.Results Levels of Scr and Cys C at 24 h after operation and BUN at 24 h and 48 h after operation significantly increased than those before operation in both groups(all P ＜ 0.05).Levels of Scr and Cys C at 24 h after operation and BUN at 24 h and 48 h after operation in observation group were significantly lower than those in control group [(77 ± 12) umol/L vs (91 ±21) μmol/L,(1.10 ±0.32)mg/L vs (1.29 ± 0.31) mg/L,(7.8 ±2.3)mmoL/L vs (9.9 ±2.0)mrnol/L,(7.5 ± 2.3) mmol/L vs (9.2 ± 2.1) mmol/L] (all P ＜ 0.05).There were no significant difference of urine volumes during operation and within 24 h after operation between observation group and control group (both P ＞ 0.05).Conclusion Dexmedetomidine can reduce renal injury in patients undergoing coronary artery bypass grafting with extracorporeal circulation.