Related factors of ascending aorta diameter in patients with hypertension complicated with obstructive sleep apnea hypopnea syndrome
Qu Fengxue
Zeng Rong
Yu Jing
Cheng Wenli
Wang Zuoguang
Abstract：Objective To analyze the related factors of ascending aorta diameter in patients with essential hypertension(EH) complicated with obstructive sleep apnea hypopnea syndrom (OSAHS).Method From January to December 2017,236 EH patients were enrolled in Beijing Anzhen Hospital,Capital Medical University.According to the apnea hypopnea index (AHI) monitored by polysomnography,the patients were divided into control group(AHI ＜5 times/min,57 cases),mild OSAHS group(AHI 5-15 times/min,57 cases),moderate OSAHS group(AHI 16-30 times/min,61 cases) and severe OSAHS group(AHI ＞ 30 times/min,61 cases).Ascending aorta diameter,ambulatory blood pressure,fasting blood glucose,triglyceride,high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol (LDL-C),blood urea nitrogen and serum creatinine were detected.Influence factors of ascending aorta diameter were analyzed by multiple stepwise regression.Results Diameter of ascending aorta in mild,moderate and severe OSAHS groups was significantly less than that in control group [(34.3 ± 0.5),(34.4 ± 0.4),(35.2 ± 0.5) mm vs (32.0 ± 0.5) mm] (all P ＜ 0.05) and the diameter widened among mild,moderate and severe OSAHS groups(P ＞ 0.05).The 24 h heart rate and daytime heart rate in severe OSAHS group were higher than those in other groups;24 h diastolic blood pressure and daytime diastolic blood pressure in moderate and severe OSAHS groups were higher than those in control group;nocturnal diastolic blood pressure in severe group was higher than that in control group;nocturnal heart rate in severe group was higher than that in moderate group (all P ＜ 0.05).Stepwise regression analysis showed that ascending aorta diameter was positively correlated with age,abdominal circumference,nocturnal diastolic blood pressure,nocturnal heart rate,AHI and it was negatively correlated with total cholesterol level;regression equation:Y=18.469 + 0.083 × age + 0.086 × abdominal circumference + 0.078 × nocturnal diastolic blood pressure + 0.081 × nocturnal heart rate + 0.027 × AHI-1.023 × total cholesterol.Conclusion EN with OSAHS patients have broadened diameter of ascending aorta;the diameter of ascending aorta is closely related with diastolic blood pressure,AHI,heart rate,age and abdominal circumference;these factors can result in macrovasular diseases.
Keywords：Essential hypertensionObstructive sleep apnea hypopnea syndromeApnea hypoventilation indexAscending aorta diameterAmbulatory blood pressure
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 827-831 )