Changes and prognostic values of serum B-type natriuretic peptide and left ventricular ejection fraction in patients with heart failure
Li Ya
Jia Xinwei
Feng Cuina
Feng Huiping
Zhao Wenping
Abstract：Objective To observe the changes of serum B-type natriuretic peptide (BNP and left ventricular ejection fraction(LVEF) in patients with heart failure and to analyze their predictive values for the prognosis.Methods Ninety-three patients with heart failure admitted to Affiliated Hospital of Hebei University from January 2015 to December 2016 were enrolled.According to the New York Heart Association cardiac function classification,the patients were divided into grade]] group(21 cases),grade Ⅲ group(52 cases) and grade ⅣV group(20 cases).All patients had anti-heart failure treatment.Levels of serum BNP and LVEF were detected before and after treatment.Re-admission and death were recorded in 1 year after discharge;serum BNP level was analyzed among patients with different outcomes.Results After treatment,serum BNP level decreased and LVEF increased compared to those before treatment (all P ＜ 0.05).Before and after treatment,serum BNP level increased and LVEF decreased among grade Ⅱ,grade Ⅲ and grade Ⅳ groups(all P ＜0.05).Within 1 year after treatment,40 patients were re-admitted and 5 patients died.Patients with re-admission had higher serum BNP level than those who were not admitted to hospital within 1 year;serum BNP level of patients who died within 1 year were higher than that of the survivors [(943 ± 276) ng/L vs (785 ± 230) ng/L,(998 ± 294) ng/L vs (615±287)ng/L](t =3.016,P=0.003;t =2.903,P=0.005).Conclusion Serum BNP combined with LVEF can reflect the cardiac function of patients with heart failure;serum BNP has a high predictive value for the prognosis of heart failure.
Keywords：Heart failureB-type natriuretic peptideLeft ventricular ejection fraction
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 823-826 )