Clinical effect of urinastatin on post-traumatic acute lung injury
Duan Xiaoli
Zhang Sai
Tu Yue
Wang Zhenguo
Liu Yang
Abstract：Objective To evaluate the effect of urinastatin on respiratory function and prognosis in patients with post-traumatic acute lung injury (ALI). Methods Clinical randomized controlled trials of urinastatin treating post-traumatic ALI were searched in Chinese and English databases. Arterial partial pressure of oxygen (PaO2) ,arterial partial pressure of carbon dioxide (PaCO2) ,PaO2 /inhaled oxygen concentration (FiO2) , incidence of acute respiratory distress syndrome(ARDS) and mortality were analyzed between urinastatin group (treated by urinastatin on the basis of routine therapy) and control group(treated by routine therapy) through meta analysis. Results Seven literatures were included in meta analysis. Compared with the control group,the urinastatin group showed significant increases in PaO2 [mean difference = 11.05,95％ confidence interval(CI): 4.59-17.50,P < 0.05]and PaO2 /FiO2 (mean difference = 65.35,95％ CI: 17.52-113.18,P = 0.007). There was no statistical significance of PaCO2 between the control group and urinastatin group(P = 0.87). Incidence of ARDS and mortality rate in urinastatin group were significantly lower than those in control group (odds ratio =0.34,0.31; 95％CI: 0.20-0.60,0.15-0.65; both P < 0.05). Conclusion Urinastatin can improve respiratory function and prognosis of patients with post-traumatic acute lung injury.
Keywords：Post-traumatic acute lung injuryUrinastatinMeta analysis
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 693-697 )