Correlation between serum uric acid level and ascending aorta diameter in patients with primary hypertension

Qu Fengxue; Zeng Rong; Yu Jing; Cheng Wenli; Wang Zuoguang

doi:10.3760/j.issn.1673-4777.2019.05.007

Abstract：Objective To investigate the correlation between serum uric acid level and ascending aorta diameter in patients with primary hypertension(HP). Methods Clinical data of 275 HP patients admitted to Beijing Anzhen Hospital,Capital Medical University between April 2013 and April 2014 were retrospectively analyzed. According to ascending aorta diameter measured by echocardiography,the patients were divided into observation group(≥35 mm,130 cases) and control group(< 35 mm,145 cases). Influence factors of ascending aorta diameter were analyzed among the clinical data,serum uric acid level,24 h ambulatory blood pressure monitoring parameters through multivariate logistic stepwise regression. Diagnostic value of serum uric acid level for ascending aorta diameter extension was analyzed through receiver operating characteristics (ROC ) curve. Results Serum uric acid level in observation group was significantly higher than that in control group[(373 ± 10) μmol /L vs (314 ± 10) μmol /L](P < 0.001). The 24 h mean systolic pressure,daytime mean systolic pressure,nocturnal mean systolic pressure,24 h mean diastolic pressure,daytime mean diastolic pressure and nocturnal mean diastolic pressure in observation group were significantly higher than those in control group(all P <0.05). Multivariate logistic stepwise regression showed that serum uric acid level was related with ascending aorta diameter(β = 0.700,P < 0.05). ROC curve showed that the critical point of serum uric acid in the diagnosis of ascending aorta diameter extension was 348.35 μmol /L; the sensitivity was 59.2％ and the specificity was 61.0％. Conclusion There is a clear correlation between serum uric acid level and ascending aorta diameter in HP patients; serum uric acid is a risk factor of ascending aorta diameter extension.