Correlation among serum ischemic modified albumin,homocysteine and coronary atherosclerotic heart disease and the diagnostic value of combined detection
Fu Jianping
Zhang Yu
Xu Bin
Zheng Qun
Zhang Huijing
Abstract：Objective To investigate the correlation among serum ischemic modified albumin (IMA) , homocysteine(Hcy) and coronary atherosclerotic heart disease (CHD) and the diagnostic value of combined detection of IMA and Hcy for CHD. Methods From March 2015 to July 2018,126 CHD patients including 28 cases of ST-segment elevation acute coronary syndrome(STEACS) ,32 cases of non-ST-segment elevation acute myocardial infarction(NSTEMI) ,30 cases of unstable angina pectoris(UAP) ,36 cases of stable angina pectoris (SAP) ,33 cases of single-vessel disease,48 cases of dual-vessel disease,45 cases of multi-vessel disease,and 120 healthy people were enrolled in People's Hospital of Hengshui. Serum levels of IMA and Hcy were measured. Correlations of IMA and Hcy with the type and severity of CHD were analyzed. Diagnostic values of combined and separate detection of IMA and Hcy were analyzed. Results Levels of serum IMA and Hcy in patients with UAP, NSTEMI and STEACS were significantly higher than those in SAP and healthy subjects[(87 ± 12) ,(110 ± 11) , (122 ± 13) kU/L vs (70 ± 10) ,(68 ± 10 ) kU/L; (15.7 ± 2.5 ) (21.7 ± 3.1 ) ,(26.6 ± 3.5 ) μmol /L vs (10.0 ± 1.2) ,(9.4 ± 1.0) μmol /L](all P < 0.05). Levels of serum IMA and Hcy increased among patients with single-vessel disease,dual-vessel and multi-vessel disease[(80 ± 5) kU/L vs (86 ± 5) ,(92 ± 6) kU/L; (10.5 ± 1.3) μmol /L vs (11.8 ± 1.6) ,(16.3 ± 1.2) μmol /L](all P < 0.05). Spearman analysis showed that serum IMA level was positively correlated with the type(from mild to severe) and severity(number of lesions) of CHD (r = 0.803,P < 0.001; r = 0.512,P = 0.008); serum Hcy level was positively correlated with the type and severity of CHD(r = 0.745,P < 0.001; r = 0.486,P = 0.013). Combined detection of IMA and Hcy showed higher diagnostic specificity and accuracy than IMA to Hcy separate detection(96.03％ vs 81.75％,76.19％; 84.96％ vs 77.64％,75.61％) (all P < 0.05) but there was no significant difference of diagnostic specificity among them(P > 0.05). Conclusions CHD patients have abnormally elevated levels of serum IMA and Hcy, which are positively correlated with the type and severity of disease. Combined detection of IMA and Hcy can improve the diagnostic accuracy and sensitivity without affecting the specificity,providing powerful reference for clinical identification,illness evaluation,reasonable therapeutic choice and prognostic prediction of CHD.
Keywords：Coronary atherosclerotic heart diseaseIschemic modified albuminHomocysteineDiagnostic value
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 664-668 )