Effect of butylphthalide combined with alteplase on acute ischemic stroke, serum inflammatory factors and neurotransmitters

Zhao Jie; Piao Xiangyu; Wu Yue

doi:10.3760/j.issn.1673-4777.2019.04.019

Abstract：Objective To explore the effect of butylphthalide combined with alyeplase on acute ischemic stroke,serum inflammatory factors and neurotransmitters.Methods A total of 95 patients with acute ischemic stroke were prospectively enrolled from May 2015 to March 2018 in Affiliated Zhongshan Hospital of Dalin University.They were randomly divided into observation group(n =48) and control group(n =47).On the basis of conventional treatments,the control group had alteplase intravenous thrombolysis;the observation group had intravenous administration of butyphthalide combined with alteplase.After 2 weeks of treatment,National Institutes of Health Stroke Scale(NIHSS) score,clinical efficacy,inflammatory factors,neurotransmitters and adverse reactions were analyzed.Results After treatment,NIHSS score significantly decreased and the score in the observation group was lower than that in the control group[(6.2 ± 1.0) vs (9.2 ± 1.2)] (P ＜ 0.0 1).Clinical effective rate in the observation group was significantly higher than that in the control group [93.8％ (45/48) vs 78.7％ (37/47)](P ＜ 0.05).Serum levels of interleukin-2,interleukin-6,C-reactive protein and tumor necrosis factorα in the observation group were significantly lower than those in the control group (P ＜ 0.01).Serum levels of 5-hydroxytryptamine and dopamine in the observation group were significantly higher while glutamate and aspartate levels were lower than those in the control group (P ＜ 0.05 or P ＜ 0.01).Conclusion Butyphthalide combined with alteplase helps to alleviate neurological deficit of ischemic stroke patient and improve the clinical efficacy,which may be related to inhibiting inflammatory response and regulating neurotransmitter level.