Expressions of found in inflammatory zone 1, interleukin-4 and γ-interferon in diffuse interstitial lung disease and the effect on clinical outcomes

Liao Yang; Jiang Yu; Luo Chun; Cheng Sheng

doi:10.3760/j.issn.1673-4777.2019.04.016

Abstract：Objective To explore the expressions of found in inflammatory zone 1 (FIZZ1),interleukin-4 (IL-4) and γ-interferon (γ-IFN) in diffuse interstitial lung disease (DILD) and the effect on clinical outcomes.Methods A total of 37 patients diagnosed of DILD in University-Town Hospital of Chongqing Medical University from January to December 2011 were prospectively enrolled.Expressions of FIZZ1 protein and FIZZ1 mRNA in lung tissue,expressions of IL-4 and γ-IFN in bronchoalveolar lavage fluid were detected before and 3 months after treatment.The patients were divided into effective group and ineffective group according to the clinical outcomes.Results All patients were followed up for 3 months;27 cases were improved(effective group) and 10 cases were ineffective(ineffective group).After treatment,expression levels of FIZZ1 protein,FIZZ1 mRNA and IL-4 in the effective group were significantly lower than those in the ineffective group [(0.49 ± 0.12) vs (0.71 ± 0.18),(0.68 ± 0.19) vs (0.92 ± 0.23),(45 ± 8) ng/L vs (105 ± 9) ng/L];expression level of γ-IFN in the effective group was significantly higher than that in the ineffective group[(28 ± 5) ng/L vs (15 ± 3) ng/L] (P ＜ 0.05).Before treatment,FIZZ1 protein and mRNA expressions were positively correlated with IL-4 level(r =0.637,P ＜ 0.001;r =0.624,P ＜ 0.001) and they were negatively correlated with γ-IFN level (r =-0.529,P ＜ 0.001;r =-0.511,P ＜ 0.001).Conclusions There an interaction among expressions of FIZZ1,IL-4 and γ-IFN in patients with DILD and the expression levels are associated with clinical outcomes.Down-regulation of FIZZ1,IL-4,γ-IFN can inhibit early pulmonary fibrosis,restrain pulmonary dysfunction,improve quality of life;these factors mav be new biomarkers for prognostic prediction of DILD.