Effect of different autologous blood separation ratio on coagulation function in patients undergoing acute aortic dissection surgery
He Chen
Pei Xin
Zhao Liyun
Ma Jun
Abstract：Objective To analyze the effect of different autologous blood separation ratio on coagulation function in patients undergoing acute aortic dissection surgery with deep hypothermic circulatory arrest.Methods Clinical data of 270 patients who underwent acute type A aortic dissection surgery (Bentall + Sun's surgery) under deep hypothermic circulatory arrest in Beijing Anzhen Hospital,Capital Medical University Between September 2015 to May 2018 were retrospectively analyzed.According to autologous blood separation ratio,the patients were divided into group A(＜ 15 ml/kg,94 cases),group B(15-20 ml/kg,91 cases) and group C(＞20 ml/kg,85 cases).Blood routine and coagulation indexes before and after surgery,intraoperative transfusion volume,blood loss and operative time were recorded.Transfusion volumes of suspended red blood cell,plasma and platelet during and after surgery were calculated.Results Intraoperative blood loss,red blood cell transfusion rate,plasma transfusion rate,plasma transfusion volume and washed red blood cell volume in group B and C were significantly less than those in group A (all P ＜ 0.05).After surgery,activated partial thromboplastin time was significantly shorter,transfusion rates of red blood cell,plasma,platelet and transfusion volume of platelet were significantly less in group B and C than those in group A[(33 ±6),(33 ±6) s vs (36 ±6)s;58.2％ (53/91),63.5％ (54/85) vs 72.3％ (68/94);22.0％ (20/91),24.7％ (21/85) vs 37.2％ (35/94);27.5 ％ (25/91),39.4％ (25/85) vs 41.5％ (39/94);1 (1,1),1 (1,1) U vs 1 (1,2) U] (all P ＜ 0.05).There was no significant difference in postoperative coagulation function and allogeneic blood transfusion data between group B and group C(P ＞ 0.05).Conclusion Autologous blood separation of 15-20 ml/kg plays a protective role in acute aortic dissection surgery;＞ 20 ml/kg autologous blood separation shows no obvious advantage.
Keywords：Acute aortic dissectionAutologous plateletphoresisAutologous blood separation ratioCoagulation function
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 517-521 )