Effect of ticagrelor on serum inflammatory factors and adverse cardiovascular events in elderly patients with unstable angina pectoris

Zeng Qingze; Liu Jiaxing; Yang Congde; Cai Zhiwei; Xie Xianxue; Huang Huaibin

doi:10.3760/j.issn.1673-4777.2019.04.005

Abstract：Objective To investigate the effect of ticagrelor on serum inflammatory factors and adverse cardiovascular events in elderly patients with unstable angina pectoris (UAP).Methods A total of 96 patients with UAP admitted to the 180th Hospital of Chinese People's Liberation Army from January 2016 to September 2017 were enrolled.They were randomly divided into control group and observation group,with 48 cases in each group.The control group took aspirin and clopidogrel.The observation group took aspirin and ticagrelor.Clinical effective rate,times of weekly angina attacks,duration of angina attack,serum inflammatory factors[interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α),high-sensitivity C-reactive protein (hs-CRP)],adverse cardiovascular events and adverse drug reactions were analyzed.Results The total effective rate in observation group was significantly higher than that in control group [89.6％ (43/48) vs 72.9％ (35/48)] (P =0.036).During the 12th month of treatment,weekly angina attacks and the duration of angina in observation group were significantly less/shorter than those in control group[(1.6 ± 1.0) times vs (2.6 ± 1.1) times,(2.2 ± 1.1) min vs (3.5 ± 1.2) min] (P ＜0.05).Twelve months after treatment,serum levels of IL-6,TNF-α and hs-CRP in observation group were significantly lower than those in control group [(2.1 ± 1.0) ng/L vs (3.2 ± 1.0) ng/L,(125 ± 21) μg/L vs (185 ± 24) μg/L,(1.2 ± 1.0) mg/L vs (2.2 ± 1.0) mg/L] (P ＜0.05).No adverse cardiovascular events such as cardiac death,myocardial infarction,heart failure and ischemic stroke were reported.Incidence of adverse reactions showed no significant difference between groups (P =0.695).Conclusion Compared with clopidogrel,ticagrelor has a better therapeutic effect on UAP in the elderly;ticagrelor can significantly reduce angina attacks and serum inflammatory factors;the safeties of the two drugs are comparable.