Effect of atorvastatin on ventricular remodeling and serum levels of chitinase-3-like protein-1 and matrix metalloproteinase-9 in patients with chronic heart failure with preserved ejection fraction
Zheng Xueou
Liu Huifeng
Hua Xianping
Huang Nanqing
Abstract：Objective To explore the effect of atorvastatin on ventricular remodeling and serum levels of chitinase-3-like protein-1 (CHI3L1) and matrix metalloproteinase-9(MMP-9) in patients with chronic heart failure with preserved ejection fraction.Methods Totally 180 patients with chronic heart failure with preserved ejection fraction admitted to Xiaolan Hospital Affiliated to Southern Medical University from January 2017 to May 2018 were randomly divided into observation group and control group,with 90 cases in each group.The control group was treated with routine therapy.The observation group was treated with atorvastatin on the basis of routine therapy.Ventricular remodeling indexes,levels of serum CHI3L1 and MMP-9 were analyzed.Results There was no significant difference of ventricular remodeling indexes,serum CHI3L1 and MMp-9 levels between groups before treatment(P ＞0.05).After treatment,early diastolic peak velocity deceleration time,early diastolic mitral flow velocity to early diastolic mitral annulus velocity ratio,left atrial volume index,left atrial mass index,CHI3L1 and MMP-9 levels significantly decreased and they were significantly lower in observation group than those in control group[(202 ±43)ms vs (252 ±56)ms,(8 ±3) vs (11 ±4),(30 ±6)mL/m2 vs(36 ±7)ml/m2,(126 ±8)g/m2 vs (146 ±9)g/m2,(226 ± 102) μg/L vs (290 ± 116) μg/L,(62 ±5)μg/L vs (105 ±8) μg/L];early diastolic mitral flow velocity to late diastolic mitral flow velocity ratio significantly increased and the value in observation group was significantly higher than that in control group[(1.14±0.22) vs (0.95 ±0.19)](all P＜0.05).Conclusion In the clinical treatment of chronic heart failure with preserved ejection fraction,the use of atorvastatin on the basis of routine treatment can significantly alleviate ventricular remodeling,reduce serum CHI3L1 and MMP-9 and promote cardiac function recovery.
Keywords：Chronic heart failureAtorvastatinPreserved ejection fractionVentricular remodelingChitinase-3-like protein-1Matrix metalloproteinase-9
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 489-492 )