Effects of clopidogrel versus ticagrelor on graft patency after coronary artery bypass grafting
Wang Deguang
Zhou Yujie
Liu Yan
Zhao Qi
Ma Yue
Peng Wenlong
Zhang Jinglin
Zhu Yong
Liu Meng
Liu Xiaoli
Zhou Zhiming
Abstract：Objective To compare the effects of ticagrelor and aspirin versus clopidogrel and aspirin on 1 year graft patency after coronary artery bypass grafting(CABG).Methods From January 2016 to June 2017,576 patients with coronary atherosclerotic heart disease were successfully treated by CABG in Beijing Anzhen Hospital,Capital Medical University,and received double antiplatelet therapy after operation.According to the antiplatelet regimen,the patients were divided into ticagrelor group (283 cases) and clopidogrel group (293 cases).Patency rate of bridge vessels,incidences of major adverse cardiovascular events (MACE) and bleeding events were analyzed 1 year after operation.Results Postoperative follow-up was completed in 264 cases in ticagrelor group and 269 cases in clopidogrel group.A total of 1 652 bridge vessels including 834 in clopidogrel group and 818 in ticagrelor group were assessed.There was no significant difference of the I year patency rate of bridge vessels between ticagrelor group and clopidogrel group [88.5 ％ (724/818) vs 85.5 ％ (713/834)] (P =0.068).There was no significant difference of incidence of MACE between groups (P =0.571).Incidence of non-CABG-related bleeding events in ticagrelor group was significantly higher than that in clopidogrel group[19.3％ (51/264) vs 11.5％ (31/269)] (P =0.013).Conclusions There is no significant difference between ticagrelor + aspirin and clopidogrel + aspirin on graft patency in 1 year after CABG.Further researches are needed to assess the long-term prognosis and bleeding risk.
Keywords：Coronary artery bypass graftingAntiplatelet therapyClopidogrelTicagrelorGraft patency
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 481-484 )