Clinical effect of early enteral nutrition support therapy with different nutrients on patients with severe cerebral hemorrhage

Li Song; Shao Hongyuan; Zhang Yonghong; Tian Ye; Li Yun

doi:10.3760/j.issn.1673-4777.2019.03.016

Abstract：Objective To analyze the clinical effect of early enteral nutrition support therapy with different nutrients on patients with severe cerebral hemorrhage.Methods A total of 100 patients with severe cerebral hemorrhage in People's Hospital Affiliated to Shanxi Medical University were enrolled between September 1st,2016 and August 31st,2018.The patients were randomly divided into observation group and control group,with 50 cases in each group.The control group had enteral nutrition support with self-made homogenate and the observation group was treated by nutritional emulsion.Levels of serum total protein,prealbumin,albumin and hemoglobin,score of Acute Physiology and Chronic Health Evaluation]Ⅱ (APACHE Ⅱ) and incidence of digestive complications were analyzed.Results There was no significant difference of nutrition indexes and APACHE Ⅱ score between groups before treatment(P ＞0.05).After 10 d treatment,levels of serum total protein,prealbumin,albumin and hemoglobin were improved in observation group and they were significantly higher than those before treatment and those in control group [(75 ± 3) g/L vs (62 ± 4) g/L,(269 ± 42) mg/L vs (224 ± 32) mg/L,(48.2 ± 3.1) g/L vs (28.4 ± 1.6) g/L,(133 ± 6) g/L vs (100 ± 15) g/L] (all P ＜ 0.05);APACHE Ⅱ score decreased significantly and the score in observation group was lower than that in control group[(10.1 ± 2.6) vs (18.4 ± 2.6)] (P ＜ 0.05).Incidence of digestive complications in observation group was significantly lower than that in control group[14.0％ (7/50) vs 38.0％ (19/50)] (P ＜0.01).Conclusion Enteral nutrition support therapy with nutritional emulsion treating severe cerebral hemorrhage can markedly improve nutrition status and resistibility of patients,reduce complications and improve the prognosis.