Effect of sedation and analgesia bundle on delirium and prognosis in cerebral infarction patients receiving mechanical ventilation
Wang Meng
Zhang Sai
Tu Yue
Zhang Jingtong
Wang Zhenguo
Liu Yang
Abstract：Objective To investigate the effect of sedation and analgesia bundle on delirium and the prognosis in cerebral infarction patients undergoing mechanical ventilation.Methods A prospective randomized controlled trail was performed in 60 cerebral infarction patients of 35-55 years old undergoing mechanical ventilation in intensive care unit(ICU) of Characteristic Medical Center of Chinese People's Armed Police Forces between January and June 2018.The patients were randomly divided into control group treated by routine nurisng (first class) and observation group treated by sedation and analgesia bundle on the basis of routine nursing,with 30 cases in each group.Length of ICU stay,4-week survival rate and incidence of delirium were analyzed.Results ICU duration in the intervention group was significantly shorter than that in the control group [(12 ± 5) d vs (17 ± 8) d] (t =2.53,P =0.014).The 4-week survival rate in the intervention group was significantly higher than that in the control group [86.7 ％ (26/30) vs 63.3 ％ (19/30)] (x2 =4.36,P =0.037).The incidence of delirium in the intervention group was significantly lower than that in the control group [23.3％ (7/30) vs 66.7％ (20/30)] (x2 =11.38,P =0.001).Conclusion Application of sedation and analgesia bundle can reduce the incidence of delirium and improve the clinical outcome of cerebral infarction patients undergoing mechanical ventilation.
Keywords：Cerebral infarctionMechanical ventilationDeliriumBundleSedation and analgesia
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 370-373 )