Correlation between plasma levels of homocysteine, uric acid, hypersensitive C-reactive protein and coronary atherosclerotic heart disease
Hu Xinke
Li Shijing
Hu Taohong
Liu Xiaohua
Li Jiadan
Feng Jing
Miao Junfeng
Abstract：Objective To explore the correlation of plasma levels of homocysteine(Hcy),uric acid (UA),hypersensitive C-reactive protein(hs-CRP) and coronary atherosclerotic heart disease (CHD).Methods Clinical data of 205 patients who were suspiciously diagnosed as CHD in Beijing Mentougou District Hospital between August 2017 to October 2018 were retrospectively retrieved.According to coronary angiography results,the patients were divided into no-CHD group (35 cases) and CHD group (170 cases).According to the severity of coronary artery lesion,they were divided into single-lesion group (56 cases),dual-lesion group (64 cases) and triple-lesion group(50 cases).Plasma levels of Hcy,UA,hs-CRP and blood lipids were recorded.Correlation between the indicators and severity of CHD was analyzed.Results Levels of Hcy,UA,hs-CRP,triglyceride,total cholesterol and low-density lipoprotein cholesterol(LDL-C) in CHD group were significantly higher than those in non-CHD group [(24.0 ± 8.0)μmol/L vs (8.6 ± 1.6) μmol/L,(455 ± 60) μmol/L vs (249 ± 48) μmol/L,(11.0 ±3.8) mg/L vs (5.1 ± 1.0)mg/L,(2.9 ±0.7) mmol/L vs (1.4 ±0.6) mmol/L,(6.0 ± 1.8) mmol/L vs (4.0 ± 0.6) mmol/L,(4.1 ± 0.8) mmol/L vs (1.6 ± 0.5) mmol/L];level of high-density lipoprotein cholesterol (HDL-C) in CHD group was significantly lower than that in non-CHD group [(0.9 ± 0.4) mmol/L vs (2.6 ± 0.4)mmol/L] (all P ＜0.001).Levels of Hcy,UA and hs-CRP in dual-lesion group and triple-lesion group were significantly higher than those in single-lesion group;levels of total cholesterol and LDL-C in triple-lesion group were significantly higher than those in single-lesion group(all P ＜0.05);levels of triglyceride and HDL-C showed no significant difference among the three groups (all P ＞ 0.05).Levels of plasma Hcy,UA and hs-CRP were positively correlated with the severity of coronary artery disease (r =0.723,0.697,0.774,all P ＜ 0.001).Conclusion Plasma levels of Hcy,UA and hs-CRP were positively correlated with the severity of coronary artery lesion,indicating possible predictive value for the diagnosis of CHD.
Keywords：Coronary atherosclerotic heart diseaseHomocysteineUric acidHypersensitive C-reactive protein
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 342-345 )