Effect of ticagrelor combined with recombinant human brain natriuretic peptide on microcirculation improvement and myocardial injury markers in patients with acute myocardial infarction after percutaneous coronary intervention
Liu Honghong
Liu Zhaochuan
Zhang Yuji
Zhang Donghua
Zhang Jingmei
Li Zhizhong
Abstract：Objective To observe the effect of combined use of ticagrelor and recombinant human brain natriuretic peptide on microcirculation improvement and myocardial injury markers in patients with acute myocardial infarction(AMI) after percutaneous coronary intervention(PCI).Methods Clinical data of 165 AMI patients who underwent PCI in Beijing Anzhen Hospital,Capital Medical University from January to December 2017 were retrospectively analyzed.They were divided into group A (treated with ticagrelor,n =55),group B (treated with recombinant human brain natriuretic peptide,n =55) and group C (treated with ticagrelor and recombinant human brain natriuretic peptide,n =55).Creatine kinase isozyme (CK-MB),cardiac troponin Ⅰ (cTnI),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),left ventricular mass index(LVMI) and thrombolysis in myocardial infarction peffusion grading (TMPG) were analyzed.Results After treatment,CK-MB,cTnI,LVEDD,LVMI significantly decreased and LVEF significantly increased in all the three groups(all P ＜ 0.05).There was no significant difference of them between group A and B (all P ＞ 0.05);CK-MB,cTnI,LVEDD and LVMI in group C were significantly lower and LVEF was significantly higher than those in group A and B[(95 ±11)U/L vs (113 ±15),(112 ± 13) U/L;(0.53 ±0.05)μg/L vs (0.72 ±0.09),(0.68 ±0.08) μg/L;(55.0±1.6)mm vs (57.9±1.7),(57.2 ± 1.8)mm;(132 ±6) vs (136 ±7),(136 ±7);(56 ±4)％ vs (53 ±4)％,(53 ±3)％] (all P ＜0.05).There were significant differences of TMPG 0-1 and 2-3 of group C (3 cases of grade 0-1 and 52 cases of grade 2-3) compared to those in group A(12 cases of grade 0-1 and 43 cases of grade 2-3) and group B(10 cases of grade 0-1 and 45 cases of grade 2-3) (x2 =6.317,P =0.042;x2 =6.153,P =0.044);but no marked difference was noticed between group A and B (P ＞ 0.05).Conclusion Combined use of ticagrelor and recombinant human brain natriuretic peptide can significantly improve microcirculation after PCI in patients with AMI,reduce serum myocardial injury markers,improve cardiac function and the prognosis.
Keywords：Acute myocardial infarctionTicagrelorRecombinant human brain natriuretic peptideMicrocirculationMyocardial injury marker
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 330-334 )