Clinical effect of sacubitril valsartan sodium tablets on hypertensive patients with chronic heart failure in plateau area
Li Jiang
Cao Jianing
Danzeng Luobu
Liu Wenxian
Kang Yunpeng
Zhu Jiajia
Zhang Jing
Sheng Jin
Ren Yanlong
Abstract：Objective To evaluate the clinical effect of sacubitril valsartan sodium tablets on patients with hypertension and chronic heart failure (CHF) in plateau area.Methods Ninety-six patients with CHF caused by hypertension were enrolled in Lhasa People's Hospital from October 2017 to February 2018.They were randomly divided into observation group (47 cases) and control group (49 cases).The observation group took sacubitril valsartan sodium tablets 100 mg twice per day and the control group took enalapril maleate 10 mg twice per day on the basis of routine treatment for heart failure for 6 months.Main outcome measurements included left ventricular ejection fraction (LVEF) and 6 minutes walking distance (6MWD).Secondary outcome indicators included total death,cardiogenic death,readmission due to heart failure,systolic blood pressure,estimated glomerular filtration rate(eGFR) and blood potassium level.Results After 6 months of treatment,LVEF and 6MWD in observation group were significantly higher/longer than those in control group [(38 ± 4) ％ vs (36 ± 4) ％,(325 ± 70) m vs (274 ± 72)m] (both P ＜ 0.05).Systolic blood pressure significantly decreased after treatment in both groups (P ＜ 0.05),but there was no significant difference between them(P ＞0.05).There was no significant difference of eGFR and blood potassium between groups before and after treatment(all P ＞0.05).Readmission rate due to heart failure within 6 months in observation group was significantly lower than that in control group[21.3％ (10/47) vs 42.9％ (21/49)](P ＜0.05).There was no significant difference of total mortality and cardiogenic mortality between groups[2.1％(1/47) vs2.0％(1/49),2.1％(1/47) vs2.0％(1/49)](P＞0.05).Conclusion Sacubitril valsartan sodium tablets treating hypertensive patients with CHF at high altitude can more effectively improve left ventricular function,exercise tolerance,quality of life,reduce recurrence and readmission than enalapril.
Keywords：Chronic heart failurePlateau areaSacubitril valsartan sodium tabletsEnalapril
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 321-324 )