Risk factors of clopidogrel resistance in patients with type 2 diabetes mellitus
Li Hongmei
Liu Junwei
Abstract：Objective To analyze the risk factors of clopidogrel resistance in patients with type 2 diabetes mellitus.Methods Clinical data of 407 patients with type 2 diabetes mellitus admitted to General Hospital of Guangzhou Military Command of the Chinese People's Liberation Army from January 1st,2016 to December 31st,2017 were prospectively analyzed.All patients had taken clopidogrel 75 mg daily for at least 7 days.Platelet aggregation rate induced by adenosine diphosphate was tested and clopidogrel resistance was defined as platelet aggregation rate ＞ 50％.Risk factors of clopidogrel resistance were analyzed.Results Clopidogrel resistance occurred in 56 patients(13.8％).Smoking ratio,body mass index,glycosylated hemoglobin and triglyceride level in patients with clopidogrel resistance were significantly higher than those in patients without clopidogrel resistance (P ＜ 0.05).Logistic regression analysis showed that glycosylated hemoglobin(odds ratio =2.463,95％ confidence interval:0.912-6.651) and triglyceride(odds ratio =2.215,95％ confidence interval:1.032-3.432) were risk factors of clopidogrel resistance (both P ＜ 0.05).Conclusion High levels of glycosylated hemoglobin and triglyceride are risk factors of clopidogrel resistance in patients with type 2 diabetes mellitus.
Keywords：Type 2 diabetes mellitusClopidogrel resistanceLogistic regression
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 246-248 )