Efficacy and safety of insulin aspart 30 in initial type 2 diabetes and long course type 2 diabetes with poor glycemic control

Zhong Weili; Zou Guoliang

doi:10.3760/j.issn.1673-4777.2019.02.021

Abstract：Objective To analyze the efficacy and safety of insulin aspart 30 in the treatment of initial type 2 diabetes and long course type 2 diabetes with poor glycemic control.Methods Totally 126 patients with type 2 diabetes were enrolled from First Affiliated Hospital,Heilongjiang University of Chinese Medicine between January 2016 and June 2018,including 66 cases of initial diabetes (course of disease ＜ 1 year,group A) and 60 cases with poor glycemic control(course of disease ＞ 5 years,group B).All patients were treated with insulin aspart 30 subcutaneous injection 3 times per day on the basis of diet and exercise intervention.Preprandial and postprandial blood glucose levels were tested at admission,2 weeks and 3 months after treatment.Daily insulin dose to reach the standard blood glucose level was recorded during hospitalization.Glycosylated hemoglobin (HbA1c) level,changes of hypoglycemic regimen and incidence of hypoglycemia were analyzed 3 months after treatment.Results Preprandial and postprandial blood glucose levels of 3 meals and blood glucose level at bedtime 2 weeks and 3 months after treatment were significantly lower than those at admission in both group A and group B (P ＜ 0.05).Daily insulin dose during hospitalization in group A was significantly lower than that in group B [(36 ±5)U/d vs (52 ± 12)U/d] (P ＜0.05).HbA1c level at admission was similar between groups(P ＞0.05).HbA1c level 3 months after treatment was significantly lower than that at admission in group A and group B [(7.3±0.3)％ vs (9.8 ±0.8)％,(7.5 ±0.5)％ vs (9.8 ±0.6)％] (P ＜0.05).At 3 months after treatment,18 of 66 patients in group A(27.3％) had insulin aspart 30 injection 2 times per day;22 patients (33.3％) took hypoglycemic agents orally;26 patients (39.4％) stopped hypoglycemic medication;all the 60 patients in group B still need insulin subcutaneous injection;6 patients(10.0％) had insulin aspart 30 injection 2 times per day;16 patients(26.7％) continued to have insulin aspart 30 injection 3 times per day;38 patients (63.3％) had insulin aspart 30 injection 2 times per day plus oral hypoglycemic agents.There was no significant difference of the incidence of hypoglycemia between groups during 3 months of treatment (P ＞ 0.05).Conclusion Intensive insulin aspart 30 treatment is safe and effective in treating initial type 2 diabetes and long course type 2 diabetes with poor glycemic control.