Effect of cinepazide maleate combined with monosialotetrahexosylganglioside sodium on serum fibulin-5 and cholinesterase in patients with acute cerebral infarction

Yu Hongmei; Huang Qingfeng

doi:10.3760/j.issn.1673-4777.2019.02.019

Abstract：Objective To investigate the effect of cinepazide maleate combined with monosialotetrahexosylganglioside sodium on serum fibulin-5 and cholinesterase in patients with acute cerebral infarction.Methods Totally 130 patients with acute cerebral infarction were enrolled from January 2015 to January 2018 in Haian Hospital of Traditional Chinese Medicine,Jiangsu Province.They were randomly divided into observation group and control group,with 65 cases in each group.On the basis of conventional therapy,the control group was treated with cinepazide maleate and the observation group was treated with monosialotetrahexosylganglioside sodium plus cinepazide maleate.Clinical efficacy,Barthel index,levels of serum cholinesterase and fibulin-5 were analyzed.Results After 2 weeks of treatment,the total effective rate in observation group was higher than that in control group [89.2％ (58/65) vs 76.9％ (50/65)] (P ＜0.05).There was no significant difference of Barthel index,serum levels of cholinesterase and fibulin-5 between groups before treatment (P ＞ 0.05).After 2 weeks of treatment,Barthel index and serum cholinesterase level increased and showed significant differences between observation group and control group[(76 ± 7) vs (54 ± 8),(4 784 ± 226) U/L vs (3 307 ± 236) U/L];serum fibulin-5 level decreased after treatment and the level in observation group was lower than that in control group [(70 ± 31)μg/L vs (90 ± 32) μg/L] (P ＜ 0.05).Conclusions Monosialotetrahexosylganglioside sodium combined with cinepazide maleate has good therapeutic effect on acute cerebral infarction.It can improve the hypoxic-ischemia of brain tissue,reduce serum fibulin-5,increase cholinesterase level and improve the prognosis and living ability.