Clinical effect of tiotropium bromide combined with salmeterol/fluticasone propionate on stable chronic obstructive pulmonary disease
Fu Yu
Wu Shaomin
Lu Hailan
Zeng Zhaofan
Abstract：Objective To explore the effect of tiotropium bromide combined with salmeterol/fluticasone propionate on stable chronic obstructive pulmonary disease(COPD).Methods A total of 126 patients with COPD at stable phase admitted to Hainan General Hospital were randomly divided into control group and observation group,with 63 cases in each group.The control group was given salmeterol/fluticasone propionate on the basis of routine oxygen inhalation and prevention of infection;the observation group was given tiotropium bromide powder inhalation on the basis of control group.Lung function indexes,score of St.George's Respiratory Questionnaire (SGRQ),6 min walking distance(6MWD),level of serum high-sensitivity C-reactive protein(hs-CRP),arterial blood gas indexes,adverse reactions and acute attack of COPD were analyzed.Results After treatment,forced vital capacity (FVC),the first second forced expiratory volume (FEV1),FEV1/FVC,6MWD and arterial partial pressure of oxygen significantly increased compared to those before treatment;the indexes in observation group were significantly higher than those in control group [(2.88 ± 0.23) L vs (2.61 ± 0.27) L,(2.26 ± 0.86) L vs (1.84±0.22)L,(66±10)％ vs (59±10)％,(392±25)m vs (319 ±25)m,(76±8)mmHg vs (60± 7)mmHg] (all P ＜ 0.05).SGRQ score,hs-CRP level and partial pressure of carbon dioxide significantly decreased after treatment;the indexes in observation group were significantly lower than those in control group [(32±5) vs (46 ±4),(16 ±3)mg/L vs (23 ±3)mg/L,(43 ±7)mmHg vs (46 ±7)mmHg] (all P＜0.05).There was no significant difference of adverse reactions between control group and observation group[25.4％ (16/63) vs 39.7％ (25/63)] (P ＞0.05).The acute attack rate of COPD in control group was significantly higher than that in observation group [22.2％ (14/63) vs 7.9％ (5/63)] (x2 =5.02,P ＜ 0.05).Conclusion Tiotropium bromide combined with salmeterol/fluticasone propionate treating stable COPD can significantly improve lung function,activity tolerance and quality of life,inhibit inflammatory response and control disease progression with good safety.
Keywords：Chronic obstructive pulmonary diseaseTiotropium bromideSalmeterol/fluticasone propionate
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 208-211 )