Therapeutic effect of nasal continuous positive airway pressure on chronic heart failure complicated with obstructive sleep apnea hypopnea syndrome

Guo Jianmei; Zhao Jihong

doi:10.3760/j.issn.1673-4777.2019.02.011

Abstract：Objective To observe the effect of nacal continuous positive airway pressure (CPAP) on patients with chronic heart failure(CHF) complicated with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods A total of 108 CHF with OSAHS patients admitted to Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces from June 2015 to November 2017 were randomly divided into observation group(n =60) and control group(n =48).The control group was treated with conventional medication;the observation group was treated with CPAP on the basis of coventional medication;all patients were treated for 12 weeks.Apnea hypopnea index(AHI),mean apnea time(MAT),mean arterial oxygen saturation (MSaO2),left atrial diameter(LA),left ventricular end-diastolic dimension (LVEDD),left ventricular posterior wall thickness (LVPW),left ventricular ejection fraction(LVEF) and brain natriuretic peptide(BNP) were analyzed.Results Before treatment,there was no significant difference in sleep monitoring parameters and echocardiographic parameters between groups(P＞0.05).After treatment,AHI,MAT,LA,LVEDD,LVPW,BNP in the observation group were significantly lower than those before treatment and those in the control group [(7.4 ± 2.9) times/h vs (52.5 ±13.1),(51.8 ±10.4) times /h;(7 ±4)s vs (46 ±8),(47 ±7)s;(39 ±4)mm vs (42 ±5),(41 ±5)mm;(49 ±3)mm vs (54 ±4),(54 ±4)mm;(8.7 ±1.4)mm vs (11.3 ± 1.7),(10.3 ±1.5)mm;(194 ± 70) ng/L vs (401 ± 90),(409 ± 80)ng/L];MSaO2 and LVEF in the observation group were significantly higher than those before treatment and those in the control group [(93.3 ± 1.8) ％ vs (79.7 ± 3.7) ％,(81.2 ± 4.1) ％;(51 ±4)％ vs (45 ±9)％,(45 ±6)％] (all P＜0.05).Conclusion CPAP can improve hypoxia and cardiac function in patients with CHF and OSAHS.