Effect of levosimendan on patients with left heart dysfunction supported by intra-aortic balloon pump after cardiac surgery
Liu Yazhou
Hou Xiaotong
Jia Ming
Wang Hong
Li Chenglong
Abstract：Objective To investigate the effect of levosimendan on patients with left heart dysfunction supported by intra-aortic balloon pump(IABP) after cardiac surgery.Methods Clinical data of 205 patients who had left heart dysfunction within 24 hours after cardiac surgery supported by IABP in Beijing Anzhen Hospital,Capital Medical University from July 2015 to March 2017 were retrospectively analyzed.The patients were divided into levosimendan group(n =90) and control group (n =115).In-hospital mortality,mechanical ventilation time,IABP time and hospitalization time were analyzed.Results After propensity score matching,128 patients were finally included,with 64 cases in each group.There was no significant difference of in-hospital mortality between groups before and after propensity score matching [21.1％ (19/90) vs 27.8％ (32/115),21.9％ (14/64) vs 21.9％ (14/64)] (P ＞ 0.05).After propensity score matching,mechanical ventilation time and IABP time in levosimendan group were significantly shorter than those in control group [(134 ± 119)h vs (254 ± 271)h,(5 ±2) d vs (7 ± 4) d] (P ＜ 0.05).Hospitalization time and postoperative complication rate showed no significant difference between groups (P ＞ 0.05).Conclusion Levosimendan can not reduce the in-hospital mortality in patients with left heart dysfunction supported by IABP after cardiac surgery,but the mechanical ventilation time and IABP use time can be shortened.
Keywords：Left heart dysfunctionIntra-aortic balloon pumpMortalityLevosimendanCardiac surgery
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 200-204 )