Relation between blood pressure variability and renal injury in patients with H-type hypertension
Wu Yi
Wang Tong
Chen Liping
Li Rui
Huang Dehui
Ke Shulan
Abstract：Objective To explore the relation between blood pressure variability and renal injury in patients with H-type hypertension.Methods A total of 127 patients with hypertension were enrolled from January 2017 to May 2018 in Lishui Hospital of Traditional Chinese Medicine.The patients were divided into observation group[Homocysteine(Hcy)≥ 10 mmol/L,86 cases] and control group(Hcy ＜ 10 mmol/L,41 cases).Systolic and diastolic blood pressure variation coefficients during the day,night and 24 h,urinary albumin,glomerular filtration rate and serum creatinine were measured.Results Systolic blood pressure variation coefficients during the day,night,24 h and 24 h diastolic blood pressure variation coefficient in observation group were significantly higher than those in controlgroup[(14.1 ±3.3) vs (11.6 ±3.0),(10.6 ±2.8) vs (8.3 ±2.8),(12.5 ± 4.4) vs (9.6 ± 3.5),(10.3 ± 2.9) vs (8.1 ± 3.1)] (P ＜ 0.05).Urinary albumin level in observation group was significantly higher and glomerular filtration rate was significantly lower than those in control group [(126 ±66) mg/gCr vs (79 ± 37) mg/gCr,(93 ± 15) ml/(min · 1.73 m2) vs (105 ± 14) ml/(min · 1.73 m2)] (P ＜0.01).There was no significant difference of serum creatinine between groups(P ＞ 0.05).The 24 h systolic and diastolic blood pressure variation coefficients were risk factors of urinary albumin and glomerular filtration rate(P ＜ 0.05).Creatinine was only associated with the 24 h systolic blood pressure variation coefficient (P ＜ 0.05).Conclusion Blood pressure variability is a risk factor of renal injury in patients with H-type hypertension.
Keywords：H-type hypertensionBlood pressure variabilityRenal injury
Publication Date：2019-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 166-169 )